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  4. Recombinant Drosophila melanogaster Protein kinase shaggy (sgg), partial

Recombinant Drosophila melanogaster Protein kinase shaggy (sgg), partial

  • 中文名称：
    黑腹果蝇sgg重组蛋白
  • 货号：
    CSB-YP325983DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇sgg重组蛋白
  • 货号：
    CSB-EP325983DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇sgg重组蛋白
  • 货号：
    CSB-EP325983DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇sgg重组蛋白
  • 货号：
    CSB-BP325983DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇sgg重组蛋白
  • 货号：
    CSB-MP325983DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    sgg
  • Uniprot No.：
    P18431
  • 别名：
    sgg; gsk3; zw3; CG2621; Protein kinase shaggy; EC 2.7.11.1; Protein zeste-white 3
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for several developmental events such as syncytial blastoderm formation and embryonic segmentation. Is involved in transcriptional regulation. Required for arm phosphorylation. Wg signaling operates by inactivating the sgg repression of en autoactivation. Negatively controls the neuromuscular junction (NMJ) growth in presynaptic motoneurons. Plays a role in the regulation of microtubule dynamics and actin cytoskeleton during embryogenesis. Required for phosphorylation of sra in activated eggs. Essential for completion of meiosis, possibly by triggering calcineurin activation via sra phosphorylation. Phosphorylates microtubule-associated protein futsch in axons.
  • 基因功能参考文献：
    1. Our findings demonstrated that lovastatin restored LRRK2-G2019S neurite degeneration by augmenting Akt/NRF2 pathway and inhibiting downstream GSK3b activity, which decreased phospho-tau levels. We suggested that lovastatin is a potential disease-modifying agent for LRRK2-G2019S parkinsonism. PMID: 26931464
    2. Mitochondrial function leads to extensive glycogen accumulation late in oogenesis and is required for the developmental competence of the oocyte. Decreased insulin signaling initiates ETC remodeling and mitochondrial respiratory quiescence through glycogen synthase kinase 3 (GSK3). PMID: 26824655
    3. Drosophila-based findings highlight an apical role for Hyd and Sgg in initiating Hedgehog signalling, which could also be evolutionarily conserved in mammals PMID: 26334301
    4. Results show that downregulation of GSK3 promotes synapse formation in Drosophila neurons. However in rats hippocampal neurons, GSK3 inhibition yields to decrease of synapses in young neurons culture and the opposite in aged culture. PMID: 25764078
    5. upregulation of Nebula/DSCR1 is neuroprotective in the presence of APP upregulation and provides evidence for calcineurin inhibition as a novel target for therapeutic intervention in preventing axonal transport impairments associated with AD PMID: 24086147
    6. The Par-1/GSK-3/Slimb pathway plays important roles in limiting the amount of pole plasm posteriorly and in degrading any mislocalized Oskar that results from leaky translational repression. PMID: 23948254
    7. GSK-3 is required for biderectional axonal transport. PMID: 23279138
    8. findings suggest a mechanism in which Shaggy/GSK-3beta activates calcineurin through Sarah phosphorylation on egg activation in Drosophila PMID: 22421435
    9. roles for the kinases GSK3 and aPKC in cellular alignment, asymmetric protein distribution, and adhesion during the development of this polarized tissue PMID: 21483653
    10. Insulin induces Myc protein accumulation in Drosophila S2 cells, which correlates with a decrease in the activity of glycogen synthase kinase 3-beta (GSK3beta ) a kinase that is responsible for Myc protein degradation. PMID: 21951762
    11. Wg signaling via Zw3 and mad restricts self-renewal of sensory organ precursor cells PMID: 21868604
    12. The kinase Sgg modulates temporal development of macrochaetes in Drosophila by phosphorylation of Scute and Pannier. PMID: 22159580
    13. GSK3 phosphorylation of Mad inhibits both BMP and Wg signaling. PMID: 21990430
    14. Perturbation of the Akt/Gsk3-beta signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs. PMID: 21518731
    15. P188 affects stress-related p38 signaling, apoptosis-related GSK3, and inflammation-related IL-6 signaling. PMID: 20736797
    16. Tau phosphorylation by Sgg at Thr212/Ser214 is important for Gly2019Ser to cause dendrite degeneration, which can be blocked by dominant-negative Sgg. PMID: 20881132
    17. The Drosophila homolog of glycogen synthase kinase-3 (GSK-3)beta, Shaggy, is required for ethanol-induced apoptosis. PMID: 19923438
    18. GSK3beta affects apical-basal polarity and cell-cell adhesion by regulating aPKC levels. PMID: 19422025
    19. Sgg/GSK3 acts in conjunction with PKA to cause hyperphosphorylation of Ci, which targets it for proteolytic processing, and that Hh opposes Ci proteolysis by promoting its dephosphorylation. PMID: 11912487
    20. Co-expression of human tau and constitutively active glycogen-synthase kinase-3beta (GSK-3beta) enhances and two GSK-3beta inhibitors, lithium and AR-A014418, reverse both the axon transport and locomotor phenotypes. PMID: 14993907
    21. Expression of Shaggy (Sgg) in motoneurons controls neuromuscular junction growth. PMID: 15269269
    22. Shaggy (Sgg)46 protein is cleaved by the Dark-dependent caspase; cleavage converts it to an active kinase, which contributes to the formation of neural precursor (sensory organ precursor (SOP)) cells PMID: 16222340
    23. at least one GSK3beta phosphorylation site of MAP1B is conserved in Futsch and that this site can be phosphorylated by GSK3beta and its Drosophila homologue, Shaggy/Zeste-white 3 PMID: 16949836
    24. shaggy functions in different neuronal circuits to regulate behavioral plasticity to an olfactory startle and circadian rhythmicity PMID: 17360579
    25. shaggy, negatively influences AP-1-dependent synaptic growth, by modulating the Jun-N-terminal kinase pathway, and also regulates presynaptic neurotransmitter release at the larval neuromuscular junction. PMID: 18832361
    26. Tau mutant resistant to phosphorylation by GSK-3beta/Shaggy retained substantial toxicity. PMID: 18930955
    27. Zw3 plays a role in the maintenance of the mitotic spindle. PMID: 19029800
    28. Gsk-3beta is a key sensor involved in neural circuit integrity, maintaining axon stability through neural activity and the Wnt pathway PMID: 19304886
    29. Mutation of ck1alpha or -epsilon or sgg/gsk3beta in wing imaginal discs results in the accumulation of dMyc protein, suggesting a physiological role for these kinases in vivo. PMID: 19364825
    30. inhibition of the serine-threonine kinase GSK-3beta completely suppresses the active zone development in Neuromuscular Junction of Drosophila. PMID: 19759297

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cell cortex. Cell junction, synapse. Cell projection, axon. Note=In syncytial embryos, detected at the centrosomes throughout the cell cycle, and in the mitotic spindle and pseudocleavage furrows invaginating from the cell cortex during mitosis. Concentrated at the growing end of membranes during the cellularization process. After cellularization, localized to the centrosomes during mitosis and to the nucleus at the end of telophase. Enriched in the presynaptic side of the neuromuscular junction, with some signal detected also in axonal branches.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, GSK-3 subfamily
  • 组织特异性：
    Expressed in ovaries and activated eggs (at protein level). Expression is over all the embryo at all stages, no local accumulation is observed.
  • 数据库链接：

    KEGG: dme:Dmel_CG2621

    STRING: 7227.FBpp0304140

    UniGene: Dm.7795

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