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  4. Recombinant Drosophila melanogaster Protein doublesex (dsx), partial

Recombinant Drosophila melanogaster Protein doublesex (dsx), partial

  • 中文名称：
    黑腹果蝇dsx重组蛋白
  • 货号：
    CSB-YP329367DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇dsx重组蛋白
  • 货号：
    CSB-EP329367DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇dsx重组蛋白
  • 货号：
    CSB-EP329367DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇dsx重组蛋白
  • 货号：
    CSB-BP329367DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇dsx重组蛋白
  • 货号：
    CSB-MP329367DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    dsx
  • Uniprot No.：
    P23023
  • 别名：
    dsx; CG11094Protein doublesex
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Controls somatic sexual differentiation. Binds directly and specifically to the FBE (fat body enhancer) of the yolk protein 1 and 2 genes (Yp1 and Yp2). This enhancer is sufficient to direct the female-specific transcription characteristic of the Yp genes in adult fat bodies. Involved in regulation of male-specific expression of takeout in brain-associated fat body.
  • 基因功能参考文献：
    1. The sex determination genes fruitless and doublesex, and a sex-specific P1-DN1 neuronal feedback govern the interaction between sleep and sexual behavior. PMID: 28754889
    2. Sex differences in Drosophila somatic gene expression controlled by variation and regulation by doublesex have been scrutinized. PMID: 27172187
    3. doublesex is required in the TN1A neurons during development to increase the density of the TN1A arbors that interact with dendrites of the hg1 motoneuron. PMID: 27326931
    4. DSX targets include transcription factors and signaling pathway components providing for direct and indirect regulation of sex-biased expression PMID: 25535918
    5. Silencing doublesex expressing neurons makes females unreceptive to courtship and copulation. PMID: 24991959
    6. These results reveal a process that builds, via dsx(M) and social experience, the potential for a more flexible sexual behavior, which could be evolutionarily conserved as dsx-related genes that function in sexual development are found throughout the animal kingdom. PMID: 24439379
    7. The respective sex-specific product of the gene doublesex promotes programmed cell death of terminal neuroblasts in females, and is needed for their survival, but not proliferation, in males. PMID: 23533181
    8. These results suggest that the foreleg provides a unique opportunity for examining the context-dependent functions of DSX. PMID: 23240029
    9. dsx protein is required to induce female postmating behavioral responses PMID: 22658598
    10. Dsx is a transcriptional target of Abdominal-B, and its regulation sculpts sex-specific abdomen morphology. PMID: 22488883
    11. This chapter reviews the role of doublesex and the neurons that express it in the regulation of courtship behavior. PMID: 21906537
    12. precise spatial regulation of dsx is essential for sex comb development and has played a key role in the origin and evolution of this structure PMID: 21886483
    13. Twenty-three genes are associated with both an in vivo peak in DSX binding and an optimal DSX-binding sequence, and thus are almost certainly direct DSX targets. PMID: 21652649
    14. Female-specific doublesex isoform regulates pleiotropic transcription factors to pattern genital development. PMID: 21343364
    15. Tissue-specific aspects of sexual development are jointly specified by post-transcriptional control by Sxl and by the transcriptional controls of dsx and fru expression. PMID: 20454565
    16. Disrupting doublesex gene neuronal function has profound effects on male sexual behavior; dsx-positive neurons are involved in pre- to post-copulatory female reproductive behaviors. PMID: 20305646
    17. Only in males do gustatory receptor neuron axons project across the midline of the ventral nerve cord. We show that fruitless and doublesex both contribute to establishing this sexual dimorphism. PMID: 20040498
    18. Purine-rich exon sequences are not necessarily splicing enhancer sequence in the dystrophin gene. PMID: 11781497
    19. involved in sex-specific gene regulation PMID: 12198117
    20. IX and DSX(F) function in a complex, in which IX acts as a transcriptional co-factor for the DNA-binding DSX(F). PMID: 12361959
    21. crystal structure PMID: 15213406
    22. Study results raise the possibility that a functional association between ix and dsx gene products existed before the origin of the bifunctional dsx gene used in insect sex determination. PMID: 15645316
    23. doublesex dimerization is mediated by a cryptic ubiquitin-associated domain fold and may have a role in the regulation of sexual dimorphism PMID: 16049008
    24. There are molecular links between the structure of the DM domain of dsx and its function in the regulation of sexual dimorphism. PMID: 16382145
    25. Doublesex could contribute to regulation of female-specific expression of the Ochlerotatus atropalpus Hex-1.2 gene. PMID: 16756549
    26. Without the male isoform of dsx the determination of a male-specific central nervous system and thus a full complement of male behaviors are not realized. PMID: 17716899
    27. doublesex and fruitless genes are both required in thoracic neurons to generate normal male lovesongs. PMID: 17925211
    28. The continuous expression of DSX(M) in cells contacting the germline suggests an ongoing short-range influence of the somatic sex determination pathway on germ cell development PMID: 17935627
    29. Doublesex has a role in regulation of sexual dimorphism in Drosophila melanogaster through a female-specific domain PMID: 18184648
    30. role of fruitless and doublesex in establishing sexually dimorphic features of neural circuitry and behavior [review] PMID: 19541474

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: dme:Dmel_CG11094

    STRING: 7227.FBpp0303107

    UniGene: Dm.3308

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