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  4. Recombinant Drosophila melanogaster Probable nuclear hormone receptor HR38 (Hr38), partial

Recombinant Drosophila melanogaster Probable nuclear hormone receptor HR38 (Hr38), partial

  • 中文名称：
    黑腹果蝇Hr38重组蛋白
  • 货号：
    CSB-YP344614DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇Hr38重组蛋白
  • 货号：
    CSB-EP344614DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇Hr38重组蛋白
  • 货号：
    CSB-EP344614DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇Hr38重组蛋白
  • 货号：
    CSB-BP344614DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇Hr38重组蛋白
  • 货号：
    CSB-MP344614DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hr38
  • Uniprot No.：
    P49869
  • 别名：
    Hr38; NR4A4; CG1864; Probable nuclear hormone receptor HR38; dHR38; Nuclear receptor subfamily 4 group A member 4
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to NGFI-B response elements. Plays an important role in late stages of epidermal metamorphosis.
  • 基因功能参考文献：
    1. Hr38 was identified as a novel immediate early gene that is transiently expressed in the male silkmoth Bombyx mori by female odor stimulation. Hr38 was also used as a neural activity marker in the fly Drosophila melanogaster. PMID: 24120640
    2. DHR38 might modulate the activity of the Usp-EcR heterodimer by forming complexes with both of its components PMID: 22628309
    3. dHR38-N-Terminal domain exhibits a characteristic reminiscent of pre-molten globule-like intrinsically disordered proteins PMID: 21064127
    4. Nutritional regulation of DHR38 expression maintains the proper uptake and storage of glycogen during the growing larval stage of development. PMID: 21084378
    5. A second ecdysteroid signaling pathway is mediated by DHR38. DHR38 also heterodimerizes with Ultraspiralcle, and this complex responds to a distinct class of ecdysteroids in a manner that is independent of the ecdysteroid receptor. PMID: 12809604
    6. Hr38 is a nuclear receptor which can assume an active conformation in the absence of a ligand agonist. PMID: 12852843
    7. Gain and loss of function studies also implicate DHR38, the Drosophila homolog of vertebrate NGFI-B-type nuclear receptors, as an important activator of the ACP65A gene. PMID: 16106360
    8. DHR38 may act as a positive regulator of neural Ddc expression PMID: 18059550
    9. DHR38(Y214) mutants display minor effects on ecdysone-regulated transcription at the onset of metamorphosis PMID: 19235727

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Nuclear hormone receptor family, NR4 subfamily
  • 组织特异性：
    Ubiquitously expressed in preblastoderm embryos, specifically in central nervous system and intestinal tract. Highly expressed in third instar larval imaginal disks and brain complexes, but not in ovaries.
  • 数据库链接：

    KEGG: dme:Dmel_CG1864

    STRING: 7227.FBpp0080927

    UniGene: Dm.2701

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