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  4. Recombinant Drosophila melanogaster Potassium voltage-gated channel protein eag (eag), partial

Recombinant Drosophila melanogaster Potassium voltage-gated channel protein eag (eag), partial

  • 中文名称：
    黑腹果蝇eag重组蛋白
  • 货号：
    CSB-YP312530DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇eag重组蛋白
  • 货号：
    CSB-EP312530DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇eag重组蛋白
  • 货号：
    CSB-EP312530DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇eag重组蛋白
  • 货号：
    CSB-BP312530DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇eag重组蛋白
  • 货号：
    CSB-MP312530DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    eag
  • Uniprot No.：
    Q02280
  • 别名：
    eag; CG10952; Potassium voltage-gated channel protein eag; Ether-a-go-go protein
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Structural component of a potassium channel. Mediates the potassium permeability of membranes; potassium current is regulated by CaMKII and CASK. Has a role in growth of the perineurial glial layer of the larval peripheral nerve.
  • 基因功能参考文献：
    1. These results show that even a minor change in amino acid side-chain chemistry and size can have a dramatic impact on channel biophysics, and that RNA editing is important for fine-tuning eag channel's function. PMID: 23064203
    2. our results provide evidence that EAG represents a unique K(+) channel contributing to multiple K(+) currents in motoneurons helping to regulate excitability, consistent with previous observations in the Drosophila larval muscle. PMID: 22323637
    3. results suggest an important role of the intracellular regions in the generation of Eag currents PMID: 21059657
    4. Results suggest an important role of the intracellular linker regions in Mg-dependent gating processes of Eag channels. PMID: 20855938
    5. phosphorylated and regulated by calcium/calmodulin-dependent protein kinase II PMID: 11980904
    6. positioning of S6 aromatic residues relative to the central cavity of the channel, not inactivation per se determines drug block of HERG or eag channels PMID: 12209010
    7. eag potassium channel binds and locally activates calcium/calmodulin-dependent protein kinase II PMID: 14699099
    8. G297E substitution may cause premature, prolonged, or constitutive opening of the Eag channels by favoring the "unlocked" state of the channel PMID: 16452147

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein. Note=Eag recruits CASK to the plasma membrane.
  • 蛋白家族：
    Potassium channel family, H (Eag) (TC 1.A.1.20) subfamily, Eag sub-subfamily
  • 组织特异性：
    Expressed in the axon and the terminal boutons of motor neurons.
  • 数据库链接：

    KEGG: dme:Dmel_CG10952

    STRING: 7227.FBpp0110308

    UniGene: Dm.2914

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