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  4. Recombinant Drosophila melanogaster Peripheral plasma membrane protein CASK (CASK), partial

Recombinant Drosophila melanogaster Peripheral plasma membrane protein CASK (CASK), partial

  • 中文名称：
    Recombinant Drosophila melanogaster Peripheral plasma membrane protein CASK(CASK) ,partial
  • 货号：
    CSB-YP632578DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Peripheral plasma membrane protein CASK(CASK) ,partial
  • 货号：
    CSB-EP632578DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Peripheral plasma membrane protein CASK(CASK) ,partial
  • 货号：
    CSB-EP632578DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Peripheral plasma membrane protein CASK(CASK) ,partial
  • 货号：
    CSB-BP632578DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Peripheral plasma membrane protein CASK(CASK) ,partial
  • 货号：
    CSB-MP632578DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CASK
  • Uniprot No.：
    Q24210
  • 别名：
    CASK; Caki; cmg; CG6703Peripheral plasma membrane protein CASK; dCASK; EC 2.7.11.17; Calcium/calmodulin-dependent protein kinase; CAKI; Camguk
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May regulate transmembrane proteins that bind calcium, calmodulin, or nucleotides. Functionally modulates eag potassium channels; increases eag current and whole-cell conductance. Also regulates autophosphorylation of CaMKII.
  • 基因功能参考文献：
    1. Data show that Drosophila CASK is associated with both pre and postsynaptic membranes, and that loss of presynaptic CASK leads to less evoked synaptic transmission, fewer spontaneous synaptic events, and reduced synaptic vesicle cycling. PMID: 21820054
    2. Full-length CASK-beta appears to have a unique role within central circuits that control motor output PMID: 21059886
    3. Camguk localizes to synaptic regions of the brain and associates in an ATP-regulated manner with CaMKII to catalyze formation of a pool of calcium-insensitive CaMKII. PMID: 14687552
    4. The results of this study support the involvement of CAKI in neurotransmitter release and nervous system function. PMID: 15872064
    5. the Drosophila homolog of CASK/Camguk can act as a gain controller on the transition to calcium-independence in vivo. PMID: 16880127
    6. Dneurexin (DNRX) is important for locomotion through a genetic interaction with the scaffold protein, CAKI/CMG, the Drosophila homolog of vertebrate CASK. PMID: 19379781

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein. Note=Eag recruits CASK to the plasma membrane.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily; MAGUK family
  • 组织特异性：
    During embryogenesis, larval and pupal life, found almost exclusively in the central nervous system. In the adult head found in the lamina, the neuropil of the medulla, lobula, lobula plate and in the central brain.
  • 数据库链接：

    KEGG: dme:Dmel_CG6703

    STRING: 7227.FBpp0303394

    UniGene: Dm.7404

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