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  4. Recombinant Drosophila melanogaster Neurobeachin (rg), partial

Recombinant Drosophila melanogaster Neurobeachin (rg), partial

  • 中文名称：
    黑腹果蝇rg重组蛋白
  • 货号：
    CSB-YP015482DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇rg重组蛋白
  • 货号：
    CSB-EP015482DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇rg重组蛋白
  • 货号：
    CSB-EP015482DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇rg重组蛋白
  • 货号：
    CSB-BP015482DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇rg重组蛋白
  • 货号：
    CSB-MP015482DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    rg
  • Uniprot No.：
    Q9W4E2
  • 别名：
    rg; Akap550; CG44835; Neurobeachin; A-kinase anchor protein 550; AKAP 550; Protein rugose; dAKAP550
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Required for correct retinal pattern formation and may function in cell fate determination through its interactions with the EGFR and Notch signaling pathways. Required for associative odor learning and short-term memory. Involved in development of the neuromuscular junction and the mushroom body.
  • 基因功能参考文献：
    1. adult rg loss-of-function mutants exhibit defective social interactions, impaired habituation, aberrant locomotion, and hyperactivity. PMID: 26100104
    2. This study demonistrated that functional homologies between Drosophila Rugose and mammalian NBEA that will help clarify the role of BEACH proteins in the development and function of the CNS in vivo. PMID: 23100440
    3. Drosophila spoonbill encodes a dual-specificity A-kinase anchor protein essential for oogenesis. PMID: 21983075
    4. results suggest that rg is required for correct retinal pattern formation and may function in cell fate determination through its interactions with the EGFR and Notch signaling pathways PMID: 12072466
    5. results suggest that rugose gene encodes a secondary pigment cell specific function, and plays an essential role in determining the optic lobe's structure PMID: 14708865
    6. Rugose (rg) plays an important role in the integration of different signals required for the exact regulation of cone cell development and survival. PMID: 15647755

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  • 亚细胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein. Perikaryon. Note=Found in the cortical region of perikarya with no expression in neuropil regions. Located at or near the Golgi network in perikarya of the dorsal medial cluster neurons.
  • 蛋白家族：
    WD repeat neurobeachin family
  • 组织特异性：
    In early embryos, ubiquitous expression with elevated levels in ventral furrow and flanking mesectodermal cells, neuroblasts and mesoderm. Late embryos show reduced expression in epidermis and skeletal muscle and elevated in nervous system, gut endotheliu
  • 数据库链接：

    KEGG: dme:Dmel_CG44835

    STRING: 7227.FBpp0288527

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