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  4. Recombinant Drosophila melanogaster Neurexin-4 (Nrx-IV), partial

Recombinant Drosophila melanogaster Neurexin-4 (Nrx-IV), partial

  • 中文名称：
    黑腹果蝇Nrx-IV重组蛋白
  • 货号：
    CSB-YP842455DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇Nrx-IV重组蛋白
  • 货号：
    CSB-EP842455DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇Nrx-IV重组蛋白
  • 货号：
    CSB-EP842455DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇Nrx-IV重组蛋白
  • 货号：
    CSB-BP842455DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇Nrx-IV重组蛋白
  • 货号：
    CSB-MP842455DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nrx-IV
  • Uniprot No.：
    Q94887
  • 别名：
    Nrx-IV; Nrx; CG6827; Neurexin-4; Neurexin IV
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Seems to play a role in the formation and function of septate junctions. Septate junctions, which are the equivalent of vertebrates tight junctions, are characterized by regular arrays of transverse structures that span the intermembrane space and form a physical barrier to diffusion. Required for the blood-brain barrier formation.
  • 基因功能参考文献：
    1. DNrx promotes ephrin clustering and reveals that ephrin/Eph signaling from adjacent L4 neurons restricts axonal branches of L4 neurons in columns. PMID: 28366281
    2. Daughterless and Tcf4 are expressed in postmitotic neurons in Drosophila melanogaster and mice, respectively, where they function to restrict neurite branching and synapse formation in part by restricting the expression of the cell adhesion molecule Neurexin.[Tcf4] PMID: 27050508
    3. Neurexin mediates retinoid transport and subsequent rhodopsin maturation in visual function; the Drosophila homolog of alpha-neurexin is critical for fly visual function. PMID: 23352167
    4. The regulation of glial-specific splicing of Neurexin IV requires HOW and Cdk12 activity. PMID: 22461565
    5. The first Laminin G-EGF-Laminin G module in the extracellular region of Neurexin IV is necessary for the localization of and association with Contactin. PMID: 22022470
    6. The possibility that neurexin is present postsynaptically raises new hypotheses regarding neurexin function in synapses, and our results provide new insights into the role of neurexin in synapse development PMID: 20559439
    7. Nrx IV is essential for proper Robo localization and repulsive axon guidance, and is a novel interacting partner of the Slit/Robo signaling pathway. PMID: 20410118
    8. Loss of Nrx IV leads to defects in ommatidial morphology and integrity. PMID: 18407259

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein. Cell junction, septate junction.
  • 蛋白家族：
    Neurexin family
  • 组织特异性：
    Found in septate junctions of epithelial and glial cells.
  • 数据库链接：

    KEGG: dme:Dmel_CG6827

    STRING: 7227.FBpp0075730

    UniGene: Dm.1843

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