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  4. Recombinant Drosophila melanogaster Myosin heavy chain, non-muscle (zip), partial

Recombinant Drosophila melanogaster Myosin heavy chain, non-muscle (zip), partial

  • 中文名称：
    黑腹果蝇zip重组蛋白
  • 货号：
    CSB-YP857857DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇zip重组蛋白
  • 货号：
    CSB-EP857857DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇zip重组蛋白
  • 货号：
    CSB-EP857857DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇zip重组蛋白
  • 货号：
    CSB-BP857857DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇zip重组蛋白
  • 货号：
    CSB-MP857857DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    zip
  • Uniprot No.：
    Q99323
  • 别名：
    zip; CG15792; Myosin heavy chain; non-muscle; Myosin II; Non-muscle MHC; Zipper protein
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Nonmuscle myosin appears to be responsible for cellularization. Required for morphogenesis and cytokinesis. Necessary for auditory transduction: plays a role in Johnston's organ organization by acting in scolopidial apical attachment. Interaction with the myosin ck may be important for this function.
  • 基因功能参考文献：
    1. study highlights the activity and distribution controls of basal myosin contractility mediated by cell-matrix and cell-cell adhesions, respectively, during tissue morphogenesis PMID: 28406187
    2. This study demonstrated that endogenous mechanical cues trigger biochemical pathways, generating the active morphogenetic movements shaping animal development through a mechanotransductive cascade of Myo-II medio-apical stabilization. PMID: 28112149
    3. Analyzing the dynamics of junction shortening and elongation resulting from myosin II pulses, the authors find that long pulses yield less reversible deformations, typically a signature of dissipative mechanics. This is consistent with a simple viscoelastic description, which we use to model individual shortening and elongation events. PMID: 28988857
    4. Migration of Drosophila border cells, a genetically tractable model for collective cell migration, requires nonmuscle myosin-II. PMID: 22326025
    5. Nonmuscle myosin II is required for cell proliferation, cell sheet adhesion and wing hair morphology during wing morphogenesis PMID: 20599890
    6. Our results provide evidence that Nonmuscle Myosin II is present presynaptically, is important for synaptic vesicle mobility and suggests a role for Nonmuscle Myosin II in shuttling vesicles at the Drosophila neuromuscular junction. PMID: 20233422
    7. The c-Jun N-terminal kinase pathway is essential for this myosin II localization during wound healing. PMID: 20153725
    8. zip/MyoII is responsible for generating the forces that drive cell-shape changes in each of the force-generating tissues that contribute to dorsal closure. PMID: 16360683
    9. Myosin II, or Zipper (Zip), a motor protein, regulates the rate at which ommatidia rotate: in zip mutants, the rate of rotation is significantly slowed. PMID: 17826761
    10. An MYH9 human disease model in flies. PMID: 17901043
    11. myosin II regulates higher-order organization of cells in the plane of the epithelium PMID: 17981139
    12. ectopically activating Hh signaling in fly epithelia reveals a direct relationship between the duration of exposure to this signaling pathway, the accumulation of activated Myosin II, and the degree of tissue invagination. PMID: 17981140
    13. Miranda protein forms an apical crescent at interphase, but is ubiquitously localized at prophase in a Myosin-II-dependent manner. PMID: 18398000
    14. S2 hinge region plays an important role in determining myosin kinetics and in regulating thick and thin filament lengths as well as sarcomere length. PMID: 19450484
    15. results demonstrate that myosin II dynamics are regulated by tension in a positive feedback loop that leads to multicellular actomyosin cable formation and efficient tissue elongation. PMID: 19879198

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  • 亚细胞定位：
    Cell projection, cilium. Cytoplasm.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
  • 组织特异性：
    In Johnston's organ, expressed in neurons and scolopale cells.
  • 数据库链接：

    KEGG: dme:Dmel_CG15792

    STRING: 7227.FBpp0072306

    UniGene: Dm.2632

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