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  4. Recombinant Drosophila melanogaster Moesin/ezrin/radixin homolog 2 (Mer), partial

Recombinant Drosophila melanogaster Moesin/ezrin/radixin homolog 2 (Mer), partial

  • 中文名称：
    黑腹果蝇Mer重组蛋白
  • 货号：
    CSB-YP631546DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇Mer重组蛋白
  • 货号：
    CSB-EP631546DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇Mer重组蛋白
  • 货号：
    CSB-EP631546DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇Mer重组蛋白
  • 货号：
    CSB-BP631546DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇Mer重组蛋白
  • 货号：
    CSB-MP631546DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mer
  • Uniprot No.：
    Q24564
  • 别名：
    Mer; EMR2; CG14228Moesin/ezrin/radixin homolog 2; Ezrin-moesin-radixin 2; Merlin; dMerlin
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Mer acts synergistically along with Ex and Kibra to regulate the Hippo signaling pathway.
  • 基因功能参考文献：
    1. Here, we show that Merlin (Mer), a homolog of the human tumor suppressor neurofibromatosis 2, is required to coordinate proliferation of germline stem cells (GSCs) and somatic cyst stem cells (CySCs) in the Drosophila testis. PMID: 28566755
    2. Merlin and Kibra activate Hippo signaling in parallel to Expanded at a spatially distinct cellular domain, the medial apical cortex. PMID: 28292426
    3. Rae1 increases activation of the core kinases Hippo and Warts and plays a post-transcriptional role to increase the protein levels of the Merlin, Hippo, and Warts components of the pathway; therefore, in addition to Rae1 coordinating organ size regulation with proliferative control, we propose that Rae1 also acts in a feedback circuit to regulate pathway homeostas PMID: 27494403
    4. Sip1 facilitates the activation of Merlin as a tumor suppressor protein. PMID: 25204795
    5. These results indicate that in both Drosophila and mammals, Merlin activates Wts/Lats phosphorylation without stimulating the intrinsic kinase activity of Hpo/Mst. PMID: 24012335
    6. The result reveals role for merlin in neuronal specification and maintenance and show that the Hippo pathway is reimplemented for sensory neuron fate by combining canonical and noncanonical regulatory steps. PMID: 22055343
    7. Drosophila tumor suppressor Merlin is essential for morphogenesis of mitochondria during sperm formation PMID: 21473116
    8. The role of the functional sites of the Merlin tumor suppressor in Drosophila spermatogenesis PMID: 21254560
    9. Data demonstrate that Cdc42 and Merlin act together with Pak1 to control salivary gland lumen size. PMID: 21068057
    10. the Merlin and Lap proteins colocalized at the cortex of the wing imaginal disc cells. PMID: 20391775
    11. microtubule-dependent transport is critical for Merlin function PMID: 20368450
    12. Dynamics of the spatial organization of the chromosome set in cells of Drosophila melanogaster imaginal disks normally and under the action of the tumor-inducing mutation Merlin PMID: 20297651
    13. Merlin mutation leads to depression of vein clonal restriction property. This means that this gene is involved not only in the control of cell proliferation, but also in the control of cell mobility and adhesion. PMID: 20297652
    14. Kibra functions together with Mer and Ex in a protein complex localized to the apical domain of epithelial cells, and this protein complex regulates the Hippo kinase cascade via direct binding to Hpo and Sav. PMID: 20159598
    15. Merlin and Expanded they are required for proliferation arrest and apoptosis in developing imaginal discs.Merlin and Expanded upstream of Hippo and identify a pathway through which they act as tumour-suppressor genes. PMID: 16341207
    16. The Drosophila Neurofibromatosis 2 (NF2) tumor suppressor ortholog Merlin (Mer)controls proliferation by regulating the abundance, localization, and turnover of cell-surface receptors. PMID: 16581517
    17. The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling. PMID: 17258190
    18. Our results demonstrated for the first time the mitochondrial localization of Merlin and suggest that Merlin may play a role in mitochondria formation and function during spermatogenesis. PMID: 18186933
    19. The ectopic expression of this mutant protein leads to chromosome nondisjunction in male meiosis. PMID: 18664148
    20. Mutated Merlin phenotype shows reduced developmental time. PMID: 18687152
    21. Mer and Ex signal through the Hippo pathway in Drosophila. PMID: 19531584

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  • 亚细胞定位：
    Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Apical cell membrane. Note=Membrane-associated, adherens junctions and endocytic compartments. Cytoplasmic, punctate.
  • 组织特异性：
    Expressed predominantly in the germline. Expressed in the developing oocyte from stage 6 to the end of oogenesis and in the apical ends of follical cells from stage 10. Ubiquitous expression throughout embryogenesis with enhanced expression in mesoderm of
  • 数据库链接：

    KEGG: dme:Dmel_CG14228

    STRING: 7227.FBpp0074523

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