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  4. Recombinant Drosophila melanogaster Moesin/ezrin/radixin homolog 1 (Moe), partial

Recombinant Drosophila melanogaster Moesin/ezrin/radixin homolog 1 (Moe), partial

  • 中文名称：
    黑腹果蝇Moe重组蛋白
  • 货号：
    CSB-YP332840DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇Moe重组蛋白
  • 货号：
    CSB-EP332840DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇Moe重组蛋白
  • 货号：
    CSB-EP332840DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇Moe重组蛋白
  • 货号：
    CSB-BP332840DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇Moe重组蛋白
  • 货号：
    CSB-MP332840DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Moe
  • Uniprot No.：
    P46150
  • 别名：
    Moe; EMR1; CG10701; Moesin/ezrin/radixin homolog 1; Ezrin-moesin-radixin 1; Moesin; dMoesin; Protein D17
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in connections of major cytoskeletal structures to the plasma membrane. Together with wgn, involved in control of axon targeting of R8 and R2-R5 photoreceptors, independent of egr. In the nucleus, recruited to sites of active transcription by RNA polymerase II where it has a role in nuclear mRNA export together with the mRNA export factor PCID2 and other messenger ribonucleoprotein (mRNP) particles.
  • 基因功能参考文献：
    1. These results indicate a critical role for Moesin in both neuronal morphogenesis and long-term memory formation. PMID: 28851405
    2. The distribution of Moesin in the nucleus suggests a function in transcription and the depletion of mRNA export factors Nup98 or its interacting partner, Rae1, leads to the nuclear accumulation of Moesin, suggesting that the nuclear function of the protein is linked to mRNA export PMID: 28554770
    3. Data show that Moesin upregulation influences extra-centrosome behavior and robust bipolar spindle formation. PMID: 25772448
    4. Btsz and Moesin guide luminal membrane morphogenesis through organizing actin. PMID: 24413568
    5. The conserved C-terminal coiled-coil domain of Slik, which is necessary and sufficient for apical localization of the kinase in epithelial cells, is not required for Moesin phosphorylation but is critical for the growth-promoting function of Slik. PMID: 26170449
    6. Early endocytosis maintains normal steady-state levels of Crumbs, which recruits apical phosphorylated (active) Moesin, which in turn regulates seamless tube shape through modulation of cortical actin filaments. PMID: 25065756
    7. Moesin interacts with an unusual RhoGAP, Conundrum (Conu), and recruits it to the cell cortex to negatively regulate RhoA activity. PMID: 23468526
    8. Moesin stabilizes microtubules via a direct interaction at the cell cortex. PMID: 23857773
    9. Wgn-Moe signaling cascade plays a key role in photoreceptor target field innervations through cell autonomous and non-cell autonomous mechanisms. PMID: 23544124
    10. Drosophila melanogaster protein phosphatase type 1 beta (flapwing) co-regulates dephosphorylation and altered activity of both Merlin and Moesin. PMID: 22133918
    11. This study revealed a novel mechanism for controlling salivary gland lumen size, namely through Rho1-dependent actin polymerization and distribution and downregulation of apical phosphorylated moesin. PMID: 22071107
    12. the Pp1-87B phosphatase restricts high Moesin activity to early mitosis and down-regulates Moesin at the polar cortex, after anaphase onset. PMID: 21969469
    13. Epithelial cell without moesin show reduced cortical actin cytoskeleton, lack of junctional markers, detach from and migrate out of the epithelium suggesting a role of moesin in the stabilization of the apical-junctional domain. (Review) PMID: 21343695
    14. PtdIns(4,5)P(2) binding is essential for moesin recruitment to the membrane and for its subsequent phosphorylation. PMID: 20519583
    15. Crumbs interacts with moesin and beta(Heavy)-spectrin in the apical membrane skeleton of Drosophila. PMID: 12213838
    16. Dmoesin is required during oogenesis for anchoring microfilaments to the oocyte cortex. Alteration of the actin cytoskeleton resulting from Dmoesin mutations impairs the localization of maternal determinants, thus disrupting antero-posterior polarity. PMID: 12360288
    17. rosslinks actin and cell membrane in Drosophila oocytes and is required for OSKAR anchoring. PMID: 12477397
    18. Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity PMID: 12511959
    19. reductions in Moesin levels in the wing disc cause the formation of wing-tissue vesicles and large thickenings of the vein, corresponding to breakdowns of epithelial continuity in the wing base and modifications of Hedgehog signalling in the wing blade PMID: 16682173
    20. our results demonstrate a role for moesin in regulating synaptic growth in the Drosophila neuromuscular junction. PMID: 18161855
    21. Changes in the activity and localization of Moesin that accompany mitotic progression contribute to the establishment of a stiff, rounded cortex at metaphase and to polar relaxation at anaphase. PMID: 18207738
    22. We propose that the spatiotemporal control of moesin activation at the mitotic cortex provides localized cues to coordinate cortical contractility and microtubule interactions during cell division. PMID: 18283112
    23. These findings suggest that Ribbon and Lola Like function as a novel transcriptional cassette coordinating molecular changes at the apical membrane of epithelial cells to facilitate tube elongation. PMID: 18585700
    24. Results provide evidence that Dmoe RNA is a target of Lark during oogenesis and that it likely regulates either the splicing or translation of this RNA. PMID: 18958492
    25. Live imaging reveals that the Drosophila actin-binding ERM protein, moesin, co-localizes with the mitotic spindle. PMID: 19592131

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  • 亚细胞定位：
    Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm. Nucleus, nucleoplasm. Chromosome.
  • 数据库链接：

    KEGG: dme:Dmel_CG10701

    UniGene: Dm.6642

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