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  4. Recombinant Drosophila melanogaster Mitogen-activated protein kinase kinase kinase (slpr), partial

Recombinant Drosophila melanogaster Mitogen-activated protein kinase kinase kinase (slpr), partial

  • 中文名称：
    黑腹果蝇slpr重组蛋白
  • 货号：
    CSB-YP850200DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇slpr重组蛋白
  • 货号：
    CSB-EP850200DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇slpr重组蛋白
  • 货号：
    CSB-EP850200DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇slpr重组蛋白
  • 货号：
    CSB-BP850200DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇slpr重组蛋白
  • 货号：
    CSB-MP850200DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    slpr
  • Uniprot No.：
    Q95UN8
  • 别名：
    slpr; Mlk2; CG2272; Mitogen-activated protein kinase kinase kinase; EC 2.7.11.25; Mixed lineage kinase; Protein slipper; dMLK
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Activates the JUN N-terminal pathway during dorsal closure.
  • 基因功能参考文献：
    1. Slpr is dispensable for Eiger/TNF-induced cell death and innate immune response mediated by Tak1 PMID: 24429281
    2. a posttranslational modification on Slpr, at a conserved site among MAP3K mixed lineage kinase family members, which bolsters stress resistance with negligible effects on JNK-dependent developmental proces PMID: 22848763
    3. The N-terminal half of Slpr is involved in regulating JNK signaling. PMID: 20736302
    4. activated by ceramide PMID: 12504027
    5. evidence that dMLK/slipper can be classified as a MAPKKK family member in the activation of the JNK pathway PMID: 12676357
    6. SLPR overexpression can induce ectopic Jun-N-terminal kinase kinase signaling; SLPR protein is enriched at the epithelial cell cortex. PMID: 16888342

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  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
  • 组织特异性：
    Expressed both maternally and zygotically. Expressed uniformly in large quantities in the early embryo (stages 1-4). In the late embryo, expression is ubiquitous, but expression levels are dramatically reduced. Expressed in the adult head and thorax, and
  • 数据库链接：

    KEGG: dme:Dmel_CG2272

    STRING: 7227.FBpp0292850

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