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  4. Recombinant Drosophila melanogaster Longitudinals lacking protein, isoforms F/I/K/T (lola), partial

Recombinant Drosophila melanogaster Longitudinals lacking protein, isoforms F/I/K/T (lola), partial

  • 中文名称：
    黑腹果蝇lola重组蛋白
  • 货号：
    CSB-YP803050DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇lola重组蛋白
  • 货号：
    CSB-EP803050DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇lola重组蛋白
  • 货号：
    CSB-EP803050DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇lola重组蛋白
  • 货号：
    CSB-BP803050DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇lola重组蛋白
  • 货号：
    CSB-MP803050DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    lola
  • Uniprot No.：
    Q867Z4
  • 别名：
    lola; CG12052; Longitudinals lacking protein; isoforms F/I/K/T
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems. Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo.
  • 基因功能参考文献：
    1. In developing axons, lola cell trafficking is regulated by cGMP-dependent protein kinase. PMID: 27098704
    2. Loss of Lola Causes Brain Tumors. PMID: 24631403
    3. Different lola isoforms, each having unique C-termini and zinc finger domains, may control different aspects of proliferation and differentiation in the male germline and somatic cyst stem cell lineages. PMID: 23159836
    4. Lola suppresses expression of the actin nucleation factor Spire, and this is crucial for its ability to promote growth of motor axons in vivo. PMID: 22129300
    5. Lola is the examplar of a class of axon guidance molecules that control axon patterning PMID: 11880341
    6. Alternative splicing of the lola gene creates a family of 19 transcription factors and explains how a small genome encodes all the information that is necessary to specify the enormous diversity of axonal trajectories. PMID: 12897787
    7. lola plays a critical role in programmed cell death in the ovary PMID: 17336958
    8. We propose that Lola functions as a general transcription factor that regulates the expression of multiple genes ultimately controlling PN identity and wiring specificity. PMID: 17634136
    9. Lola antagonizes Notch-dependent gene expression and Notch-dependent fate transformation. Expression analysis shows that Lola is constitutively present in all photoreceptors and cone cells PMID: 18053694

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    By stage 11, isoform F is expressed throughout the mesoderm whereas isoform T, and at low levels isoform I, is expressed throughout the ectoderm. Isoform K is expressed in both mesoderm and ectoderm. Expression becomes restricted during later stages; star
  • 数据库链接：

    STRING: 7227.FBpp0088384

    UniGene: Dm.11710

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