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  4. Recombinant Drosophila melanogaster Lamin Dm0 (Lam), partial

Recombinant Drosophila melanogaster Lamin Dm0 (Lam), partial

  • 中文名称：
    黑腹果蝇Lam重组蛋白
  • 货号：
    CSB-YP362551DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇Lam重组蛋白
  • 货号：
    CSB-EP362551DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇Lam重组蛋白
  • 货号：
    CSB-EP362551DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇Lam重组蛋白
  • 货号：
    CSB-BP362551DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇Lam重组蛋白
  • 货号：
    CSB-MP362551DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Lam
  • Uniprot No.：
    P08928
  • 别名：
    Lam; CG6944; Lamin Dm0
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. May have a role in the localization of the LEM domain proteins Ote, bocks and MAN1 to the nuclear membrane. In spermatocytes, plays a role in maintaining type-A lamin LamC nuclear localization; regulates meiotic cytokinesis by maintaining the structure of the spindle envelope, and by contributing to the formation of the contractile ring and central spindle.
  • 基因功能参考文献：
    1. findings reveal coordination of AGO2 and LaminB function to dictate genome architecture and thereby regulate gene expression PMID: 29529026
    2. The loss of lamin-B leads to systemic inflammation and aging. PMID: 25875575
    3. nuclear Wash interacts with B-type Lamin (Lamin Dm0), and, like Lamin, Wash associates with constitutive heterochromatin PMID: 25754639
    4. of single phosphorylation sites of Drosophila melanogaster lamin Dm and lamin C PMID: 22393432
    5. Rab5 associated in vivo with nuclear Lamin and mushroom body defect (Mud), the Drosophila counterpart of nuclear mitotic apparatus protein (NuMA). PMID: 21987826
    6. Kugelkern and lamin Dm0 affect nuclear shape without requiring filament formation or the presence of a classical nuclear lamina. PMID: 20685963
    7. Lamin mutation is associated with neuromuscular defects and premature aging. PMID: 17565385
    8. analysis of Drosophila and human A-type lamins PMID: 19855837
    9. prometaphase spindle can be made robust to natural fluctuations in motor ratios by a disassembling lamin-B envelope. PMID: 20065089
    10. Null mutants of Drosophila B-type lamin Dm(0) show aberrant tissue differentiation rather than obvious nuclear shape distortion or specific defects during cell proliferation. PMID: 15996653
    11. Molecular interactions with lamin Dm0 may link JIL-1 kinase to nuclear morphology and integrity of nurse cells during oogenesis. PMID: 16254246
    12. The lamin Dm0 allele Ari3 acts as an enhancer of position effect variegation of the wm4 allele in Drosophila. PMID: 16897461
    13. Both lamin Dm0 and C. elegans Ce-lamin bind directly to histone H2A in vitro and this binding requires the nuclear localization signal PMID: 17148572
    14. Induced expression of the farnesylated lamina proteins Lamin B and Kugelkern cause aberrant nuclear shapes and reduce the lifespan of adult flies. PMID: 18494863
    15. developmental disorders caused by lesions in the B-type lamins and interacting proteins PMID: 19218438

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  • 亚细胞定位：
    Nucleus. Nucleus inner membrane. Nucleus envelope. Nucleus lamina. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm.
  • 蛋白家族：
    Intermediate filament family
  • 组织特异性：
    Constitutively expressed in all tissues (at protein level). Expressed in spermatocytes (at protein level).
  • 数据库链接：

    KEGG: dme:Dmel_CG6944

    STRING: 7227.FBpp0078733

    UniGene: Dm.312

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