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  4. Recombinant Drosophila melanogaster Insulin receptor substrate 1 (chico), partial

Recombinant Drosophila melanogaster Insulin receptor substrate 1 (chico), partial

  • 中文名称：
    Recombinant Drosophila melanogaster Insulin receptor substrate 1(chico) ,partial
  • 货号：
    CSB-YP011829DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Insulin receptor substrate 1(chico) ,partial
  • 货号：
    CSB-EP011829DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Insulin receptor substrate 1(chico) ,partial
  • 货号：
    CSB-EP011829DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Insulin receptor substrate 1(chico) ,partial
  • 货号：
    CSB-BP011829DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Insulin receptor substrate 1(chico) ,partial
  • 货号：
    CSB-MP011829DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    chico
  • Uniprot No.：
    Q9XTN2
  • 别名：
    chico; IRS; CG5686; Insulin receptor substrate 1; dIRS; Protein chico
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit. May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation.
  • 基因功能参考文献：
    1. Study shows that the insulin receptor substrate gene chico controls the functioning of the systems of metabolism of dopamine and juvenile hormone in Drosophila melanogaster females under normal conditions and in thermal stress PMID: 27599505
    2. Expressing chico(+)in the mushroom bodies(MB) restores the number of MB neurons to wild-type amounts and also rescues chico learning defects. PMID: 22342328
    3. chico acts with the transcription factor FOXO to extend Drosophila lifespan PMID: 21518241
    4. results demonstrate that chico1 induces a state equivalent to submaximal, dietary restriction-induced slowing of aging PMID: 11951037
    5. Mortality deceleration is a phenotype of chico. PMID: 12882356
    6. chico(1) ovaries transplanted into wild-type females did not undergo vitellogenesis indicating that CHICO is necessary in the ovary for vitellogenic maturation. PMID: 15890189

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  • 数据库链接：

    KEGG: dme:Dmel_CG5686

    STRING: 7227.FBpp0079677

    UniGene: Dm.3017

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