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  4. Recombinant Drosophila melanogaster Inositol 1,4,5-trisphosphate receptor (Itp-r83A), partial

Recombinant Drosophila melanogaster Inositol 1,4,5-trisphosphate receptor (Itp-r83A), partial

  • 中文名称：
    黑腹果蝇Itp-r83A重组蛋白
  • 货号：
    CSB-YP329957DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇Itp-r83A重组蛋白
  • 货号：
    CSB-EP329957DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇Itp-r83A重组蛋白
  • 货号：
    CSB-EP329957DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇Itp-r83A重组蛋白
  • 货号：
    CSB-BP329957DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇Itp-r83A重组蛋白
  • 货号：
    CSB-MP329957DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Itp-r83A
  • Uniprot No.：
    P29993
  • 别名：
    Itpr; dip; InsP3R; Itp-r83A; CG1063; Inositol 1,4,5-trisphosphate receptor; InsP3 receptor; IP3R; InsP3R
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Together with MCU, has a role in oxidative stress-induced ER-mitochondria calcium transfer. May be involved in visual and olfactory transduction, and myoblast proliferation. May be involved in ethanol tolerance.
  • 基因功能参考文献：
    1. slow imaginal disc intercellular calcium waves (SIDICs) are mediated by the inositol-3-phosphate receptor, the endoplasmic reticulum (ER) calcium pump SERCA and the key gap junction component Inx2. PMID: 27503836
    2. Study found that phototransduction was quantitatively unaffected not only after IP3R-RNAi, but also in IP3R-null mutants; describes novel phenotypes in photoreceptors from flies expressing the transcription factor (Gal4) used to drive RNAi expression. Results indicate that IP3R plays no significant role in Drosophila phototransduction while emphasizing the need for caution when using Gal4 drivers. PMID: 28660247
    3. cell-specific regulation of protein synthesis by IP3R in neuroendocrine cells influences protein metabolism. PMID: 28289132
    4. The present study shows that itpr function in peptidergic neurons is not only necessary but also sufficient for maintaining normal lipid metabolism in Drosophila. PMID: 24350669
    5. InsP3R function alters lipid metabolism and causes hyperphagia. PMID: 23471909
    6. Studies show that expression of transcripts related to carbohydrate and amine metabolism is altered in InsP(3) receptor mutant larvae. PMID: 21901161
    7. Restoring InsP(3)R-mediated Ca(2+) release and SOCE in neuromodulatory cells influences systemic behaviors such as flight by regulating intracellular Ca(2+) homeostasis in a large population of neurons through a non-cell-autonomous mechanism. PMID: 20107057
    8. ommatidia with a null mutation of IP(3)R degenerate by a process associated with intermittent lipid peroxidation and apoptotic activities PMID: 20404055
    9. data support a model where InsP(3)R activity in non-overlapping neuronal domains independently rescues larval itpr phenotypes by non-cell autonomous mechanisms PMID: 19680544
    10. Mutants of itpr, encoding inositol (1,4,5)-trisphosphate receptor (IP(3)R), attenuate response to diuretic peptides of Drosophila melanogaster renal (Malpighian) tubules PMID: 12547945
    11. Mutants in the inositol 1,4,5-trisphosphate receptor (itpr) gene exhibit delays in molting while stronger alleles are also larval lethal. There is a critical period for itpr gene function in second instar larvae. PMID: 15020420
    12. The InsP(3) receptor functions to modulate flight specifically through serotonergic interneurons. InsP(3) receptor action appears to be important for normal development of the flight circuit and its central pattern generator. PMID: 15356199
    13. Results describe single channel properties of a point mutant (G2630S) in the pore-forming region of the Drosophila inositol (1,4,5)-trisphosphate receptor . PMID: 15388340
    14. ectopic expression of the Ka901 mutant channel in aminergic cells alters electrophysiological properties of a flight circuit and results in defective flight behavior PMID: 16325255

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    InsP3 receptor family
  • 组织特异性：
    Segmental expression of isoform B is first detected in stage 13 embryos in lateral and posterior epidermis. Expression extends to head region during stages 13-17: gnathal buds, clypeolabrum, procephalic lobe, labial organ and anterior sense organs. Adults
  • 数据库链接：

    KEGG: dme:Dmel_CG1063

    STRING: 7227.FBpp0078336

    UniGene: Dm.4462

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