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  4. Recombinant Drosophila melanogaster Homeotic protein ocelliless (oc), partial

Recombinant Drosophila melanogaster Homeotic protein ocelliless (oc), partial

  • 中文名称：
    黑腹果蝇oc重组蛋白
  • 货号：
    CSB-YP326346DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇oc重组蛋白
  • 货号：
    CSB-EP326346DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇oc重组蛋白
  • 货号：
    CSB-EP326346DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇oc重组蛋白
  • 货号：
    CSB-BP326346DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇oc重组蛋白
  • 货号：
    CSB-MP326346DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    oc
  • Uniprot No.：
    P22810
  • 别名：
    oc; Otd; CG12154Homeotic protein ocelliless; Protein orthodenticle
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional regulator involved in pattern formation and cell determination in the embryonic CNS and larval imaginal disks. Also later in development to coordinate the expression of regulatory and structural genes required for photoreceptor cell fate in the ocelli. Has a dual role in the terminal differentiation of subtypes of photoreceptors by regulating rhodopsin (rh) expression: essential for establishing the expression of rh genes in the pale subset of ommatidia as well as repressing Rh6 in outer photoreceptors.
  • 基因功能参考文献：
    1. Our results indicate that the head-specific gap gene empty spiracles can act as a repressor of Toy, while ocelliless (oc) and spalt major (salm) appear to act as positive regulators of toy gene expression PMID: 26976323
    2. Otd is a main component of the gene regulatory network that regulates synaptic-column and layer targeting in the fly visual system. PMID: 26114289
    3. The conserved homeobox protein Orthodenticle acts together with the ecdysone receptor to directly repress the expression of Kruppel homolog 1. PMID: 22547825
    4. Orthodenticle is expressed in a group of clonally related dopamine neurons from first instar larvae to adulthood, making it possible to establish an identity relationship between larval and adult dopamine neuron clusters. PMID: 21999236
    5. Sequence analysis indicates that many of the transcriptional regulatory domains identified here are conserved in multiple Diptera Otd-related proteins. PMID: 20732315
    6. Although Otd and Pph13 have been implicated in rhabdomere morphogenesis, we demonstrate that it is necessary to remove both factors to completely eliminate rhabdomere formation. PMID: 20667913
    7. Mutational inactivation of otd/Otx2 and unpg/Gbx2 result in the loss or misplacement of the brain-specific expression domains of Pax2/5/8 and Hox genes. PMID: 12702651
    8. Otd is a key player in the terminal differentiation of subtypes of photoreceptors by regulating rhodopsin expression PMID: 12967559
    9. Otd as a critical regulator of photoreceptor morphology and phototransduction PMID: 18241855
    10. Data show that otd/Otx gene is involved in the specification of the anterior brain during embryonic CNS development in Drosophila. PMID: 18683636

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family
  • 组织特异性：
    Expressed in the anterior region of the embryo before cellularization and becomes localized to the procephalic head region following gastrulation. These cells correspond to the mesectoderm or midline neuroepithelium and will generate a mixed population of
  • 数据库链接：

    KEGG: dme:Dmel_CG12154

    STRING: 7227.FBpp0304126

    UniGene: Dm.2933

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