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  4. Recombinant Drosophila melanogaster Homeobox protein vnd (vnd), partial

Recombinant Drosophila melanogaster Homeobox protein vnd (vnd), partial

  • 中文名称：
    黑腹果蝇vnd重组蛋白
  • 货号：
    CSB-YP328350DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇vnd重组蛋白
  • 货号：
    CSB-EP328350DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇vnd重组蛋白
  • 货号：
    CSB-EP328350DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇vnd重组蛋白
  • 货号：
    CSB-BP328350DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇vnd重组蛋白
  • 货号：
    CSB-MP328350DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    vnd
  • Uniprot No.：
    P22808
  • 别名：
    vnd; NK2; CG6172; Homeobox protein vnd; Homeobox protein NK-2; Protein ventral nervous system defective
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable transcriptional regulator involved in the regulation of the proneural AS-C genes and the neurogenic genes of the enhancer of split complex. Could specifically activate proneural genes in the ventral-most neuroectoderm.
  • 基因功能参考文献：
    1. NKX2-5 and MLC2v double-positive cells possess ventricular-like properties. The results demonstrate that the NKX2-5(eGFP/w) and MLC2v(mCherry/w) hPSCs provide a powerful model system to capture region-specific cardiac differentiation from early to late stages. Our study would facilitate subtype-specific cardiac development and functional analysis using the hPSC-derived sources. PMID: 29175323
    2. the Neurogenic Ectoderm Enhancer (NEE) at vnd takes additional input from the complementary Dpp, dorsal, twist gradient via a conserved Schnurri/Mad/Medea silencer element (SSE) unlike NEEs at brk, sog, rho, and vn PMID: 23499655
    3. The results obtained from this study indicate that expression of at least four genes, uzip, CG7687, SytIV, and ase, are regulated by Vnd. PMID: 19863267
    4. Tthe vnd/NK-2 gene encodes an additional protein isoform (NK-2B) that differs from the known one (NK-2A) in its N-terminal domain. PMID: 21422076
    5. excludes Meltrin expression from the embryonic ventral neuroectoderm PMID: 20705134
    6. Vnd segment-specifically affects ind expression; it represses ind in the tritocerebrum but positively regulates ind in the deutocerebrum by suppressing Msh PMID: 20673828
    7. DNA-binding analysis using embryonic nuclear protein also demonstrates that Vnd interacts with other nuclear proteins, suggesting the existence of Vnd as a complex PMID: 20587330
    8. NK2 and Antp with uncharged N-tails show behavior very similar to that of truncated Antp and NK2, indicating that the disordered tails affect the unfolded state by non-native charge-charge interactions. PMID: 19919153
    9. nucleotide sequences regulate the expression of the vnd/NK-2 gene; vnd/NK-2 gene can be activated in different ways in different neuroblasts; pattern of vnd/NK-2 gene expression in neuroblasts of the ventral nerve cord is the sum of partial patterns. PMID: 11752402
    10. expression is required for both neural and glial specification PMID: 11793359
    11. In vnd mutants, head neuroectoderm Nk6 expression is abolished where it is normally co-expressed with vnd. PMID: 12128210
    12. AAGT sequence determines binding kinetics for vnd homeodomain PMID: 12232052
    13. molecular basis for the phenotypic alterations observed on ectopic expression of the Y54M vndNK-2 gene during embryogenesis PMID: 12626758
    14. structural alteration of the DNA-bound A35T mutant vnd/NK-2 protein may constitute the basis of the observed early embryonic lethality PMID: 14580198
    15. Results indicate that vnd is required for the genesis and proper identity specification of tritocerebral neural lineages during embryonic brain development of Drosophila. PMID: 17038518
    16. the Nk-2 box contributes to the repression activity of Vnd by stabilizing its interaction with the co-repressor, Groucho PMID: 17070676
    17. Data show that expression of gene vnd is invloved in dorsoventral regionalization within the developing brain and truncal nervous system in Drosophilia. PMID: 18683637

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    NK-2 homeobox family
  • 组织特异性：
    Expressed in the CNS and midgut.
  • 数据库链接：

    KEGG: dme:Dmel_CG6172

    STRING: 7227.FBpp0070105

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