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  4. Recombinant Drosophila melanogaster Histone deacetylase Rpd3 (Rpd3), partial

Recombinant Drosophila melanogaster Histone deacetylase Rpd3 (Rpd3), partial

  • 中文名称：
    黑腹果蝇Rpd3重组蛋白
  • 货号：
    CSB-YP835986DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇Rpd3重组蛋白
  • 货号：
    CSB-EP835986DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇Rpd3重组蛋白
  • 货号：
    CSB-EP835986DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇Rpd3重组蛋白
  • 货号：
    CSB-BP835986DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇Rpd3重组蛋白
  • 货号：
    CSB-MP835986DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rpd3
  • Uniprot No.：
    Q94517
  • 别名：
    HDAC1; Rpd3; CG7471; Histone deacetylase HDAC1; HD; EC 3.5.1.98
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation may constitute a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. For instance, deacetylation of histone H3 may be a prerequisite for the subsequent recruitment of the histone methyltransferase Su(var)3-9 to histones. Involved in position-effect variegation (PEV). In the larval brain, part of a regulatory network including the transcriptional repressors klu, dpn and E(spl)mgamma-HLH which is required for type II neuroblast self-renewal and for maintaining erm in an inactive state in intermediate neural progenitors (INP).
  • 基因功能参考文献：
    1. Rpd3 accumulates in the nucleolus in the early stage of starvation, upregulates rRNA synthesis, maintains the polysome amount for translation, and finally increases stress tolerance proteins, such as autophagy-related proteins, to acquire starvation stress resistance. PMID: 27907135
    2. Hdac1/Rpd3 functions together with self-renewal transcriptional repressors to maintain the erm immature intermediate neural progenitors enhancer in an inactive but poised state in neuroblasts. PMID: 28245922
    3. This study tested the longevity effects of RPD3 on multiple nutrient levels. PMID: 26647291
    4. Rpd3 deacetylase in the heart plays a significant role in cardiac function and longevity to systemically modulate the fly's response to the environment PMID: 26399365
    5. the Atro-Rpd3 complex plays a conserved role to function as a Ci(R) corepressor. PMID: 24385484
    6. The dose of Rpd3 is critical for normal long-term memory. PMID: 22195015
    7. Work suggests that Drosophila telomere structure is epigenetically regulated by the histone deacetylase Rpd3. PMID: 21625008
    8. Our study suggests a specific function for the general chromatin remodeling factor Rpd3 in regulating dendrite targeting in neurons, largely through the postmitotic action of the Pros transcription factor. PMID: 20660276
    9. role of Rpd3 deacetylase and caloric restriction in longevity regulation PMID: 12459580
    10. findings indicate that Rpd3 contributes to Knirps repression activity in vivo PMID: 16186109
    11. DHDAC1 and -3 have distinct functions in the control of gene expression PMID: 16632473

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Histone deacetylase family, HD type 1 subfamily
  • 数据库链接：

    KEGG: dme:Dmel_CG7471

    STRING: 7227.FBpp0073173

    UniGene: Dm.2976

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