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  4. Recombinant Drosophila melanogaster Histone acetyltransferase Tip60 (Tip60), partial

Recombinant Drosophila melanogaster Histone acetyltransferase Tip60 (Tip60), partial

  • 中文名称：
    黑腹果蝇Tip60重组蛋白
  • 货号：
    CSB-YP850213DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇Tip60重组蛋白
  • 货号：
    CSB-EP850213DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇Tip60重组蛋白
  • 货号：
    CSB-EP850213DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇Tip60重组蛋白
  • 货号：
    CSB-BP850213DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇Tip60重组蛋白
  • 货号：
    CSB-MP850213DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tip60
  • Uniprot No.：
    Q960X4
  • 别名：
    Tip60; CG6121; Histone acetyltransferase Tip60; EC 2.3.1.48
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalytic subunit of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, acetylates phosphorylated histone H2AV in nucleosomes on 'Lys-4' and exchanges it with unmodified H2AV.
  • 基因功能参考文献：
    1. most HIF1A targets require either TIP60, the CDK8-Mediator complex, or both as coactivators for full expression in hypoxia. PMID: 27320910
    2. Our results implicate Tip60 as a critical mediator of EE-induced benefits, and provide broad insights into synergistic behavioral and epigenetic based therapeutic approaches for treatment of cognitive disorder. PMID: 27454757
    3. compromising Tip60 histone acetyltransferase activity in the CySC lineage recapitulates loss-of-function phenotypes of E(Pc), suggesting that Tip60 and E(Pc) act together, consistent with published biochemical data. PMID: 28196077
    4. critical for morphology and function of the mushroom body PMID: 26327426
    5. Heat Shock Factor recruits the dTip60 complex to the hsp70 loci in cells treated with salicylate, which triggers chromatin remodeling at these loci without transcription activation. PMID: 24639513
    6. Excess Tip60 exerts a neuroprotective role in axonal transport and functional locomotion defects in an animal model of Alzheimer's disease. PMID: 23616558
    7. a novel mechanism for Tip60 mediated sleep-wake regulation via control of axonal growth and PDF levels within the small ventrolateral neurons-encompassing neural network PMID: 22982579
    8. a functional interaction between Tip60 and APP in mediating nervous system development and apoptotic neuronal cell death PMID: 22848598
    9. The role of Tip60 HAT activity in transcriptional control during multicellular development in vivo, was investigated. PMID: 21494552
    10. Ubiquitous dTip60 knock-down in flies was lethal, whereas knock-down in the wing imaginal disk led to developmental defects. PMID: 19949809
    11. demonstrated that the dTip60 chromatin-remodeling complex acetylates nucleosomal phospho-H2Av and exchanges it with an unmodified H2Av; both the histone acetyltransferase dTip60 and the atpase Domino/p400 catalyze the exchange of phospho-H2Av PMID: 15528408
    12. TIP60 complex can promote the generation of silent chromatin. PMID: 16816423
    13. TIP60 is differentially expressed during Drosophila development, with transcript levels significantly peaking during embryogenesis, and is essential for multicellular development. PMID: 17179074

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    MYST (SAS/MOZ) family
  • 数据库链接：

    KEGG: dme:Dmel_CG6121

    STRING: 7227.FBpp0070636

    UniGene: Dm.75

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