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  4. Recombinant Drosophila melanogaster Heat shock protein 83 (Hsp83), partial

Recombinant Drosophila melanogaster Heat shock protein 83 (Hsp83), partial

  • 中文名称：
    黑腹果蝇Hsp83重组蛋白
  • 货号：
    CSB-YP355879DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇Hsp83重组蛋白
  • 货号：
    CSB-EP355879DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇Hsp83重组蛋白
  • 货号：
    CSB-EP355879DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇Hsp83重组蛋白
  • 货号：
    CSB-BP355879DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇Hsp83重组蛋白
  • 货号：
    CSB-MP355879DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hsp83
  • Uniprot No.：
    P02828
  • 别名：
    Hsp83; Hsp82; CG1242; Heat shock protein 83; HSP 82
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation. Required for piRNA biogenesis by facilitating loading of piRNAs into PIWI proteins.
  • 基因功能参考文献：
    1. Hsp90 binds close to the transcriptional start site of around one-third of all Drosophila coding genes. PMID: 29177663
    2. We show that while Hsp70 or Hsp83 expression under normal or stress conditions was not affected by AR feeding, Hsp27 levels were elevated in AR-fed wild-type control as well as heat-shocked larvae PMID: 27966490
    3. The results revealed that the high-fat diet augmented the rate of lipid peroxidation and SOD and CAT activity and induced a higher expression of HSP83 and MPK2 mRNA. PMID: 27579152
    4. Hsp83 facilitates methoprene-tolerant nuclear import to modulate juvenile hormone signaling. PMID: 25122763
    5. Interaction of Spag with both Hsp70 and Hsp90 suggests a model whereby R2TP would accompany clients from Hsp70 to Hsp90 to facilitate their assembly into macromolecular complexes. PMID: 24394412
    6. Our results reveal that Hsp83 plays a heretofore unappreciated role in promoting APC/C function during cell cycle exit and suggest a mechanism by which Hsp90 inhibition could promote genomic instability and carcinogenesis PMID: 24086162
    7. Using computational and biochemical analyses, study find that Hsp90 maintains and optimizes RNA polymerase II pausing via stabilization of the negative elongation factor complex. PMID: 22579285
    8. Data suggest that that an Sgt1/Hsp90-LKB1-AMPK pathway acts redundantly with a microtubule-induced polarity pathway to generate neuroblast cortical polarity, and the absence of neuroblast cortical polarity can produce neuroblast tumors. PMID: 22248825
    9. A natural genetic variation in Hsp90 may mediate the evolution of canalized morphological traits even if it does not influence the expression of variation for uncanalized traits. PMID: 20200026
    10. Hsp90 is required for Ago2 to receive the small interfering RNA (siRNA) duplex from the RNA-induced silencing complex-loading complex in RNA interference. PMID: 20639883
    11. To determine the effect of Hsp90 on quantitative trait variability we deconstructed genetic, stochastic and environmental components of variation in traits of genetically matched flies, differing only by Hsp90 loss-of-function or wild-type alleles. PMID: 17183707
    12. Up to 120-fold differences in penetrance among six highly related selection lines, selected for and against a deformed eye trait, did not translate into measurable differences in viability, lifespan or competitive fitness. PMID: 17183708
    13. Hsp83 mutations can generate new variation by transposon-mediated 'canonical' mutagenesis PMID: 20062045
    14. Hsp90 masks variation affecting target pathways and traits in populations independent of purely nongenetic sources of variation PMID: 14595030
    15. heat shock inhibits eIF4F activity, and Hsp90 mRNA translation is sensitive to eIF4F inactivation PMID: 15347681
    16. The results suggest that a multicomponent protein chaperone complex involving both Hsp90 and Hsp70 signals the cessation of heat shock protein synthesis, the restoration of normal translation, and likely the establishment of thermotolerance. PMID: 16218955
    17. Data show that Smaug can recruit the CCR4-NOT deadenylase to trigger Hsp83 mRNA degradation despite the fact that it is being translated. PMID: 18794360
    18. These findings suggest that Sgt1 is involved in the stabilization of Polo allowing normal centrosome maturation, entry and progression though mitosis. PMID: 19131964
    19. Hsp90 cooperates with Trx at chromatin for maintaining the active expression state of targets like the Hox genes. PMID: 19144915

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Heat shock protein 90 family
  • 数据库链接：

    KEGG: dme:Dmel_CG1242

    STRING: 7227.FBpp0305095

    UniGene: Dm.2800

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