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  4. Recombinant Drosophila melanogaster Fibroblast growth factor receptor homolog 2 (btl), partial

Recombinant Drosophila melanogaster Fibroblast growth factor receptor homolog 2 (btl), partial

  • 中文名称：
    Recombinant Drosophila melanogaster Fibroblast growth factor receptor homolog 2(btl) ,partial
  • 货号：
    CSB-YP600971DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Fibroblast growth factor receptor homolog 2(btl) ,partial
  • 货号：
    CSB-EP600971DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Fibroblast growth factor receptor homolog 2(btl) ,partial
  • 货号：
    CSB-EP600971DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Fibroblast growth factor receptor homolog 2(btl) ,partial
  • 货号：
    CSB-BP600971DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Fibroblast growth factor receptor homolog 2(btl) ,partial
  • 货号：
    CSB-MP600971DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    btl
  • Uniprot No.：
    Q09147
  • 别名：
    btl; FR2; HD-311; Tk2; CG32134; Fibroblast growth factor receptor homolog 2; EC 2.7.10.1; Protein breathless; Tyrosine kinase 2; dTk2; Tyrosine kinase receptor HD-311; dFGF-R1
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be required for patterning of muscle precursor cells: generation of mesodermal and endodermal layers, invaginations of various types of cells, and CNS formation. Essential for the ability of the migrating tracheal and midline cells to recognize external guiding cues.
  • 基因功能参考文献：
    1. Time lapse imaging shows dynamic reorganization of branchless (bnl)-expressing cells and bnl-receptor breathless (btl) expressing trachea during embryonic development. PMID: 28502613
    2. Transgene expression of Drosophila melanogaster nucleoside kinase reverses mitochondrial thymidine kinase 2 deficiency PMID: 23288848
    3. Study demonstrates that jing is required for btl expression in the branching trachea and dominantly interacts with known regulators of btl expression, including the ETS and POU transcription factors, pointed, and drifter/ventral veinless, respectively PMID: 21061018
    4. Branchless/Breathless signaling contains a positive feedback loop, which may guarantee a continuous supply of fresh receptors to membranes of growing tracheal branch cells PMID: 12175485
    5. In embryos, Fgfr1c was detected in osteoblasts of calvarial and mandibular bones. Fgfr3b and Fgfr3c were in chondrocytes in cranial base and mandibular condyle. Fgfr2b transcripts were detected in perichondria of mandibular condyle and cranial base. PMID: 12919696
    6. Data show that Downstream-of-FGFR is a substrate for fibroblast growth factor receptors (FGFRs) and recruits Corkscrew, leading to FGF-induced cell migration and activation of the Ras/MAPK pathway. PMID: 15082772

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily
  • 组织特异性：
    During embryogenesis, expression is seen in mesoderm, endodermal precursor cells, CNS midline cells and trachea and salivary duct ectodermal cells.
  • 数据库链接：

    KEGG: dme:Dmel_CG32134

    STRING: 7227.FBpp0075520

    UniGene: Dm.10724

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