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  4. Recombinant Drosophila melanogaster E3 ubiquitin-protein ligase mind-bomb (mib1), partial

Recombinant Drosophila melanogaster E3 ubiquitin-protein ligase mind-bomb (mib1), partial

  • 中文名称：
    黑腹果蝇mib1重组蛋白
  • 货号：
    CSB-YP896152DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇mib1重组蛋白
  • 货号：
    CSB-EP896152DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇mib1重组蛋白
  • 货号：
    CSB-EP896152DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇mib1重组蛋白
  • 货号：
    CSB-BP896152DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇mib1重组蛋白
  • 货号：
    CSB-MP896152DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    mib1
  • Uniprot No.：
    Q9VUX2
  • 别名：
    mib1; mind-bomb; CG5841; E3 ubiquitin-protein ligase mind-bomb; EC 2.3.2.27; Mind bomb homolog; D-mib; RING-type E3 ubiquitin transferase mind-bomb
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase that mediates ubiquitination of Delta (Dl) and Serrate (Ser) receptors, which act as ligands of Notch proteins. Positively regulates the Notch signaling by ubiquitinating the intracellular domain of Dl and Ser, leading to endocytosis of Dl and Ser receptors. Regulates a subset of Notch signaling events, including wing margin specification, leg segmentation and vein determination, that are distinct from those events requiring neuralize (neur) activity. Also modulates lateral inhibition, a neur- and Dl-dependent signaling event, suggesting a distinct but partially complementary function with neur.
  • 基因功能参考文献：
    1. While deficient Mib1 signaling leads to overgrowth of the NMJ, ubiquitous overexpression of Mib1 results in a reduction in the number of presynaptic motor neuron boutons and branches PMID: 26596173
    2. The ubiquitylation of Delta by both Neuralized and Mindbomb1 was detected, with the two enzymes using distinct docking sites and having different acceptor lysine preferences. PMID: 22162135
    3. Mind bomb (D-mib) associates physically and functionally with both Serrate and Delta, and is a positive component of Notch signaling that is required for multiple Neuralized-independent, Notch-dependent developmental processes. PMID: 15829515
    4. Simultaneous absence of neuralized and mib1 completely abolishes Notch signaling in both lateral inhibition (generating single neural precursors from a field of equipotent cells)and wing dorsoventral boundary formation. PMID: 16093323
  • 亚细胞定位：
    Cytoplasm, cell cortex. Note=Localizes at the apical cortex of cells.
  • 组织特异性：
    Ubiquitous in the wing imaginal disk (at protein level).
  • 数据库链接：

    KEGG: dme:Dmel_CG5841

    STRING: 7227.FBpp0075275

    UniGene: Dm.10758

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