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  4. Recombinant Drosophila melanogaster Double-stranded RNA-specific editase Adar (Adar), partial

Recombinant Drosophila melanogaster Double-stranded RNA-specific editase Adar (Adar), partial

  • 中文名称：
    Recombinant Drosophila melanogaster Double-stranded RNA-specific editase Adar(Adar) ,partial
  • 货号：
    CSB-YP868262DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Double-stranded RNA-specific editase Adar(Adar) ,partial
  • 货号：
    CSB-EP868262DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Double-stranded RNA-specific editase Adar(Adar) ,partial
  • 货号：
    CSB-EP868262DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Double-stranded RNA-specific editase Adar(Adar) ,partial
  • 货号：
    CSB-BP868262DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Double-stranded RNA-specific editase Adar(Adar) ,partial
  • 货号：
    CSB-MP868262DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Adar
  • Uniprot No.：
    Q9NII1
  • 别名：
    Adar; hypnos-2; CG12598Double-stranded RNA-specific editase Adar; EC 3.5.-.-; Adenosine deaminase that act on RNA; Pre-mRNA adenosine deaminase; RNA-editing deaminase 1; RNA-editing enzyme 1; dADAR; dsRNA adenosine deaminase
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Has A-to-I RNA editing activity on extended dsRNA: edits RNA-binding protein Rnp4F. A-to-I editing of pre-mRNAs acts predominantly through nervous system targets to affect adult nervous system integrity, function and behavior. Essential for adaptation to environmental stresses, such as oxygen deprivation, and for the prevention of premature neuronal degeneration, through the editing of ion channels as targets.
  • 基因功能参考文献：
    1. our data shows that ADAR is essential for proper temperature adaptation, a key behavior trait that is essential for survival of flies in the wild. Moreover, our results suggest a more general role of ADAR in regulating RNA secondary structures in vivo PMID: 28746393
    2. Deficiencies in the RNA-editing gene Adar increase sleep due to synaptic dysfunction in glutamatergic neurons. PMID: 26813350
    3. The study demonstrates that neuronal excitability is linked to dADAR expression levels in individual neurons. PMID: 24137011
    4. loss of Adar increases quantal size, reduces the number of quanta of neurotransmitter released and perturbs the calcium dependence of synaptic release PMID: 23127996
    5. results demonstrate a novel role for dADAR protein in rnp-4f 5'-UTR alternative intron splicing regulation which is consistent with a previously proposed model. PMID: 23026215
    6. Data suggeset that RNA editing enzyme ADAR-mediated editing is more widespread than previously indicated and largely occurs cotranscriptionally. PMID: 22658416
    7. the solution structure of the N-terminal dsRNA binding domain (dsRBD) of dADAR PMID: 22210494
    8. Abolishing dADAR auto-regulation dramatically remodels the landscape of re-coding events in a site-specific manner. PMID: 22531175
    9. network-wide temporal and spatial regulation of ADAR activity can tune the complex system of RNA-editing sites and modulate multiple ethologically relevant behavioral modalities. PMID: 21078670
    10. Our study is the first to systematically characterize the temporal and spatial expression of full-length and truncated dADAR mRNA and protein isoforms during Drosophila embryogenesis. PMID: 19720447
    11. genetic analysis of dADAR substrates in Drosophila PMID: 15522950
    12. importance of ADAR in maintenance of neuronal function and regulatory role in the expression of genes encoding reactive oxygen species scavengers. PMID: 15530657
    13. Two predominant isoforms of dAdar are expressed in gonads and dAdar is transcribed from both the embryonic and the adult promoters. PMID: 19153139

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  • 组织特异性：
    Expressed in embryonic nervous system; late stage 13 sees ventral nerve cord expression which spreads to brain by stage 16. Expression is maintained through to adulthood.
  • 数据库链接：

    KEGG: dme:Dmel_CG12598

    STRING: 7227.FBpp0300329

    UniGene: Dm.19

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