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  4. Recombinant Drosophila melanogaster Dopamine D2-like receptor (D2R), partial

Recombinant Drosophila melanogaster Dopamine D2-like receptor (D2R), partial

  • 中文名称：
    黑腹果蝇Dop2R重组蛋白
  • 货号：
    CSB-YP812861DLU1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇Dop2R重组蛋白
  • 货号：
    CSB-EP812861DLU1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇Dop2R重组蛋白
  • 货号：
    CSB-EP812861DLU1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇Dop2R重组蛋白
  • 货号：
    CSB-BP812861DLU1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇Dop2R重组蛋白
  • 货号：
    CSB-MP812861DLU1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dop2R
  • Uniprot No.：
    Q8IS44
  • 别名：
    Dop2R; D2R; CG17004; Dopamine D2-like receptor; DD2R
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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Dop2R Proteins

靶点详情

  • 功能：
    Receptor for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
  • 基因功能参考文献：
    1. By means of genetic mosaicism, we identified widespread dopaminergic modulation within the olfactory circuit that suggests nonredundant and reiterating functions of D2R in support of ARM. Our results oppose ARM to its concomitant memory phases that localize to mushroom bodies and propose a decentralized organization of consolidated ARM. PMID: 27466338
    2. The results suggest that fruit flies are an excellent model system to provide some answers to previously unexplainable observations regarding the compromised dopaminergic nervous system and the related therapeutic agents. PMID: 23286280
    3. Our study also showed that rescue of dopaminergic (DA) neurodegeneration by Drosophila DD2R activation was mediated through suppression of action potentials in DA neurons. PMID: 23452092
    4. It is concluded that the change in the number of DD2Rs in corpus allatum or their activation decreases the fitness of Drosophila. PMID: 22946336
    5. mediates, at least in part, the inhibiting effect of dopamine on juvenile hormone synthesis PMID: 22206888
    6. role of DD2R in the regulation of juvenile hormone metabolism PMID: 21928133
    7. Alkaline phosphatase activity was increased in flies with reduced DD2R expression vs. corresponding controls. PMID: 20303975
    8. Data show that activation of D2-like dopamine receptors inhibits juvenile hormone degradation in female Drosophila. PMID: 20665150
    9. Molecular characterization and identification of multiple alternatively spliced variants PMID: 12391323
    10. Locomotor activity is regulated by D2-like receptors in Drosophila PMID: 17443795

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Highest expression is in adult heads.
  • 数据库链接：

    KEGG: dme:Dmel_CG33517

    STRING: 7227.FBpp0099564

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