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  4. Recombinant Drosophila melanogaster Cyclic AMP response element-binding protein A (CrebA), partial

Recombinant Drosophila melanogaster Cyclic AMP response element-binding protein A (CrebA), partial

  • 中文名称：
    Recombinant Drosophila melanogaster Cyclic AMP response element-binding protein A(CrebA) ,partial
  • 货号：
    CSB-YP328927DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Cyclic AMP response element-binding protein A(CrebA) ,partial
  • 货号：
    CSB-EP328927DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Cyclic AMP response element-binding protein A(CrebA) ,partial
  • 货号：
    CSB-EP328927DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Cyclic AMP response element-binding protein A(CrebA) ,partial
  • 货号：
    CSB-BP328927DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Cyclic AMP response element-binding protein A(CrebA) ,partial
  • 货号：
    CSB-MP328927DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CrebA
  • Uniprot No.：
    P29747
  • 别名：
    CrebA; Bbbf2; CG7450Cyclic AMP response element-binding protein A; cAMP response element-binding protein A; dCREB-A; Box B-binding factor 2; BBF-2
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator. Binds to fat body-specific enhancers of alcohol dehydrogenase (ADH) and yolk protein genes. BBF-2 may play a role in fat body gene expression. It binds the consensus sequence 5'-T[AC]NACGTAN[TG]C-3'.
  • 基因功能参考文献：
    1. Data suggest that CrebA is involved in regulation of infection tolerance in this species; expression of CrebA is regulated in the fat body upon infection; CrebA is required to survive infection and promotes tolerance of bacterial infection; CrebA deficiency leads to ER (endoplasmic reticulum) stress upon bacterial challenge. PMID: 29394281
    2. CrebA deficiency leads to ER stress upon bacterial challenge PMID: 29394281
    3. Drosophila CrebA directly binds the enhancers of secretory pathway genes and is both necessary and sufficient to activate expression of every secretory pathway component gene examined thus far. PMID: 21041443
    4. direct and indirect interactions of the hsromega transcripts with a variety of regulatory proteins like hnRNPs, CBP, proteasome, Drosophila inhibitor of apoptosis protein 1 (DIAP1) PMID: 20065067
    5. AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila PMID: 11976688
    6. CrebA activity is linked to secretory function in multiple tissues PMID: 15901661
    7. cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity. PMID: 16009936
    8. The CREB binding protein transcriptional cofactor is necessary and sufficient for down-regulation of DIAP1. PMID: 17591924

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family
  • 组织特异性：
    In all cell types examined, including developing salivary gland in embryos and in adults, brain and optic lobe cell bodies, salivary gland, midgut epithelial cells of the cardia, female ovarian columnar follicle cells and male seminal vesicle, ejaculatory
  • 数据库链接：

    KEGG: dme:Dmel_CG7450

    STRING: 7227.FBpp0089339

    UniGene: Dm.6979

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