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  4. Recombinant Drosophila melanogaster Cadherin-related tumor suppressor (ft), partial

Recombinant Drosophila melanogaster Cadherin-related tumor suppressor (ft), partial

  • 中文名称：
    黑腹果蝇ft重组蛋白
  • 货号：
    CSB-YP327232DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇ft重组蛋白
  • 货号：
    CSB-EP327232DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇ft重组蛋白
  • 货号：
    CSB-EP327232DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇ft重组蛋白
  • 货号：
    CSB-BP327232DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇ft重组蛋白
  • 货号：
    CSB-MP327232DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ft
  • Uniprot No.：
    P33450
  • 别名：
    ft; CG3352Cadherin-related tumor suppressor; Protein fat) [Cleaved into: Ft-mito]
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in regulation of planar cell polarity in the compound eye where it is required for correct specification of the R3 and R4 photoreceptor cells by regulating Fz activity in the R3/R4 precursor cells. This is likely to occur through creation of an ft gradient so that the equatorial R3/R4 precursor cell has a higher level of ft function than its polar neighbor. Also required for planar cell polarity of wing hairs. Mediates heterophilic cell adhesion in vitro and is required to stabilize ds on the cell surface. Involved in regulation of eye imaginal disk size. Upstream component of the Hippo pathway where it is likely to act as a cell surface receptor involved in regulation of tissue size and is required for the localization and stability of ex. Probably acts as a cell surface receptor for ds.; Regulates mitochondrial electron transport chain integrity and promotes oxidative phosphorylation.
  • 基因功能参考文献：
    1. Vamana associates with the Dachsous intracellular domain and with a region of the Fat intracellular domain that is essential for controlling Hippo signaling and levels of Dachs. PMID: 27746048
    2. App promotes drosophila growth via the Hippo pathway by palmitoylation of Fat protein. PMID: 28031421
    3. Study shows Drosophila Ft functions in mitochondria to directly regulate mitochondrial electron transport chain integrity and promote oxidative phosphorylation. PMID: 25215488
    4. Ft's roles in planar cell polarity signaling and tissue size control PMID: 23667559
    5. Ft and Crb act as sensors to drive cell orientation during intercalary regeneration and control Yki levels to ensure a proper balance between proliferation and cell reorientation. PMID: 23903186
    6. The human Fat homolog FAT4 lacks the ability to transduce Hippo signaling in Drosophila, but can transduce Drosophila planar cell polarity signaling. PMID: 23318637
    7. cell shape, junctional localization and cytoskeletal planar polarity in the Drosophila embryo are regulated by a common signal provided by the atypical cadherin Fat PMID: 23250217
    8. study shows how the Fat/Dachsous/Four-jointed planar cell polarity pathway controls morphogenesis PMID: 22499807
    9. Through epistasis tests, the requirement for Zyx is positioned within the Fat branch of Hippo signaling, downstream of Fat and Dco, and upstream of the Yorkie kinase Warts. PMID: 21666802
    10. Fat/Hippo pathway regulates the progress of neural differentiation signaling in the Drosophila optic lobe. PMID: 21671914
    11. We posit that Wg propels wing growth at least in part by fueling a wave front of Ft-Ds signaling that propagates vg expression from one cell to the next PMID: 20532238
    12. role in growth and planar polarity and relation to dachsous modulated by four-jointed phosphorylation PMID: 20434337
    13. Fat plays a role in the polarity and orientation of ommatidia in the Drosophila eye, and is regulated by dachsous protein. PMID: 11893338
    14. These data lead us to a model in which fat and Atro act twice in the determination of planar polarity in the eye: first in setting up positional information through the production of a planar polarity diffusible signal, and later in R3 fate determination PMID: 12506006
    15. Polarity of Drosophila wing hairs is controlled by two tiers of the planar cell polarity signalling pathway, orcestrated by fat and frizzled PMID: 12540853
    16. fat acts in parallel to EGFR pathway in transducing different cell communication signals, and its function is requested downstream of MAPK for a correct rendering of the growth signals converging to the EGFR PMID: 15652705
    17. functional relationships among D. melanogaster tumor suppressors and components of a Fat signaling pathway. PMID: 16980976
    18. Study reports that the protocadherin Fat acts as an upstream component in the Hippo pathway, Fat is a known tumor-suppressor gene in Drosophila, and fat mutants have severely overgrown imaginal discs. PMID: 16996265
    19. data suggest that Fat functions as a cell-surface receptor for the Expanded branch of the conserved Hippo growth control pathway PMID: 16996266
    20. Fat modulates Salvador/Warts/Hippo pathway activity by promoting abundance and localization of Expanded protein at the apical membrane of epithelial tissues. PMID: 17045801
    21. Fat is subject to a constitutive proteolytic processing, such that most or all cell surface Fat comprises a heterodimer of stably associated N- and C-terminal fragments. PMID: 19574458
    22. identification of a conserved cytoplasmic protein, Lowfat (Lft), as a modulator of Fat signaling PMID: 19710173
    23. Results provide evidence for a pathway in which Yorkie activity is repressed by direct physical association with three other pathway components: Expanded, Hippo, and Warts. PMID: 19733165

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Apical cell membrane.; [Ft-mito]: Mitochondrion.
  • 数据库链接：

    KEGG: dme:Dmel_CG3352

    STRING: 7227.FBpp0077167

    UniGene: Dm.293

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