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  4. Recombinant Drosophila melanogaster Ataxin-2 homolog (Atx2), partial

Recombinant Drosophila melanogaster Ataxin-2 homolog (Atx2), partial

  • 中文名称：
    Recombinant Drosophila melanogaster Ataxin-2 homolog(Atx2) ,partial
  • 货号：
    CSB-YP823422DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Ataxin-2 homolog(Atx2) ,partial
  • 货号：
    CSB-EP823422DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Ataxin-2 homolog(Atx2) ,partial
  • 货号：
    CSB-EP823422DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Ataxin-2 homolog(Atx2) ,partial
  • 货号：
    CSB-BP823422DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster Ataxin-2 homolog(Atx2) ,partial
  • 货号：
    CSB-MP823422DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Atx2
  • Uniprot No.：
    Q8SWR8
  • 别名：
    Atx2; CG5166Ataxin-2 homolog; Datx2
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    RNA binding protein that regulates various processes including circadian behaviors, actin filament formation, eye development and oocyte formation. Forms a complex with tyf and pAbp which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B. Forms an activator complex (Atx2-tyf activator complex) via association with Lsm12a and activates the TYF-dependent translation of per to maintain 24 hour periodicity in circadian locomotor behaviors. Forms a repressor complex (Atx2-Not1 repressor complex) via the me31B-dependent association with Not1 to promote Not1-dependent post-transcriptional gene silencing and support high-amplitude circadian rhythms in a per-independent manner. Regulates actin filament formation, though it does not directly assemble with actin filaments. Required for oocyte specification and oocyte positioning in the female germline. Also required for normal eye development and bristle morphology.
  • 基因功能参考文献：
    1. The Ataxin-2 protein is required for microRNA function and synapse-specific long-term olfactory habituation. PMID: 21795609
    2. dosage-sensitive regulator of actin filament formation PMID: 12524342
    3. nuclear accumulation of Ataxin-2 contributes to expanded Ataxin-1-induced toxicity PMID: 18166084
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Ataxin-2 family
  • 数据库链接：

    KEGG: dme:Dmel_CG5166

    STRING: 7227.FBpp0082555

    UniGene: Dm.1489

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