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  4. Recombinant Drosophila melanogaster ATP-dependent helicase brm (brm), partial

Recombinant Drosophila melanogaster ATP-dependent helicase brm (brm), partial

  • 中文名称：
    Recombinant Drosophila melanogaster ATP-dependent helicase brm(brm) ,partial
  • 货号：
    CSB-YP338671DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster ATP-dependent helicase brm(brm) ,partial
  • 货号：
    CSB-EP338671DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster ATP-dependent helicase brm(brm) ,partial
  • 货号：
    CSB-EP338671DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster ATP-dependent helicase brm(brm) ,partial
  • 货号：
    CSB-BP338671DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Drosophila melanogaster ATP-dependent helicase brm(brm) ,partial
  • 货号：
    CSB-MP338671DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    brm
  • Uniprot No.：
    P25439
  • 别名：
    brm; CG5942; ATP-dependent helicase brm; EC 3.6.4.12; Homeotic gene regulator; Protein brahma
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional regulator. Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters. Can counteract the repressive effect of Polycomb protein. ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. In type II neuroblast lineage, as part of the Brm remodeling complex, suppresses the formation of ectopic neuroblasts probably through interaction with erm and HDAC3.
  • 基因功能参考文献：
    1. Study characterizes the BRAHMA (BRM) chromatin-remodeling protein in Drosophila in the context of circadian clock regulation. By dissecting its catalytic vs. non-catalytic activities, we propose a model in which the non-catalytic activity of BRM functions to recruit repressive factors to limit the transcriptional output of CLK during the active phase of circadian transcription. PMID: 26926115
    2. This paper identified the Brahma (Brm) complex as a regulator of the Drosophila clock PMID: 26132408
    3. Data indicate that brahma protein (Brm) in the form of the PBAP complex functions in the germline stem cells (GSCs) fate regulation. PMID: 25068272
    4. Brahma functions as a critical regulator of Hippo signaling during tissue growth and plays an important role in the feedback loop between Crb and Yki. PMID: 25496831
    5. Brm-HDAC3-Erm repressor complex suppresses dedifferentiation of intermediate neural progenitors back into type II neuroblasts. PMID: 24618901
    6. The results show that Brm knockdown leads to nucleosome occupancy changes throughout the entire genome with a bias in occupancy decrease. PMID: 25081211
    7. Results show that the levels of BRM affect specifically the abundance of a trans-spliced mod(mdg4) mRNA isoform in both S2 cells and larvae. PMID: 24526065
    8. TnaA physically interacts with the SUMO E2 conjugating enzyme Ubc9, and with the BRM complex subunit Osa. PMID: 23620817
    9. Amongst the dominant suppressors of Drosophila cyclin E (DmcycE(JP)), identified brahma (brm) and moira (mor), which encode conserved core components of the Drosophila Brm complex PMID: 12093739
    10. complex facilitates global transcription by RNA polymerase II PMID: 12356740
    11. Consistent with this view, SNR1(E1) is stably associated with other components of the Brm complex at the restrictive temperature. PMID: 12482982
    12. SNR1 is essential for some, but not all Brm functions, and it likely serves as an optional subunit, directing Brm complex activity to specific gene loci or cellular processes. PMID: 12645932
    13. SNR1 (SNF5-Related-1), a highly conserved subunit of the Brm complex, is required to restrict complex activity during the development of wing vein and intervein cells. PMID: 15013794
    14. The abundant HMG box proteins HMGB AND HGMD participate in Brahma-dependent chromatin remodeling at a specific subset of Brahma-dependent promoters. PMID: 16299391
    15. This study reports that the Brm complex assists in coordinating hormone-dependent transcription regulation of the Eig genes. PMID: 16990270
    16. brahma chromatin-remodeling complexes interaction with gammaTub23C PMID: 18780727

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: dme:Dmel_CG5942

    STRING: 7227.FBpp0303193

    UniGene: Dm.5356

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