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  4. Recombinant Dog Tight junction protein ZO-2 (TJP2), partial

Recombinant Dog Tight junction protein ZO-2 (TJP2), partial

  • 中文名称：
    熟悉的犬TJP2重组蛋白
  • 货号：
    CSB-YP839157DO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    熟悉的犬TJP2重组蛋白
  • 货号：
    CSB-EP839157DO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    熟悉的犬TJP2重组蛋白
  • 货号：
    CSB-EP839157DO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    熟悉的犬TJP2重组蛋白
  • 货号：
    CSB-BP839157DO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    熟悉的犬TJP2重组蛋白
  • 货号：
    CSB-MP839157DO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TJP2
  • Uniprot No.：
    Q95168
  • 别名：
    TJP2; ZO2; Tight junction protein ZO-2; Tight junction protein 2; Zona occludens protein 2; Zonula occludens protein 2
  • 种属：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in tight junctions and adherens junctions.
  • 基因功能参考文献：
    1. Silencing tight junction protein ZO-2 alters epithelial cytoarchitecture.ZO-2 silencing increases RhoA activity through GEF-H1 recruitment to cell borders.ZO-2 silencing activates Cdc42 and triggers mitotic spindle disorientation. ZO-2 silencing increases Rac1 and cofilin activity and lamellipodia formation. PMID: 28554775
    2. SUMOylation affects the intracellular localization of ZO-2 and its regulatory role on GSK3beta and beta-catenin signaling activity. PMID: 27604867
    3. novel posttranslational modifications of ZO-2 regulate the intracellular fate of this protein. PMID: 23804652
    4. ZO-1 and ZO-2 proteins are required not only for TJ assembly but also for regulating the organization and functional activity of the apical cytoskeleton, particularly the perijunctional actomyosin ring; these activities are relevant both to cellular organization and epithelial morphogenesis. PMID: 22190737
    5. The identification of ZASP helps to unfold the complex nuclear molecular arrays that form on ZO-2 scaffolds. PMID: 20868680
    6. The canine sequence of ZO-2 displays four putative nuclear export signals (NES), two at the second PDZ domain (NES-0 and NES-1) and the rest at the guanylate kinase region (NES-2 and NES-3). PMID: 16920099
    7. ZO-2 silencing triggered: changes in the gate function of the TJ, changes in the fence function of the TJ; altered expression of TJ and adherens junction proteins, an atypical monolayer architecture. PMID: 17374535
    8. Constitutive expression in MDCK cells, GP8 endothelial cells nuclei leads to increase expression of the M2 pyruvate kinase,increased proliferative activity and in MDCK reduced intercellular junctional stability. PMID: 17973926
    9. ZO-2 inhibits cell proliferation at G0/G1 and decreases CD1 protein level. PMID: 19056685
    10. The departure of ZO-2 from the nucleus is regulated by phosphorylation at Ser369 by novel PKCepsilon. PMID: 19625451

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cell junction, tight junction.
  • 蛋白家族：
    MAGUK family
  • 数据库链接：

    KEGG: cfa:403854

    STRING: 9615.ENSCAFP00000002794

    UniGene: Cfa.1898

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