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  4. Recombinant Dog Superoxide dismutase [Cu-Zn] (SOD1)(X53S)

Recombinant Dog Superoxide dismutase [Cu-Zn] (SOD1)(X53S)

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  • 中文名称：
    Recombinant Dog Superoxide dismutase [Cu-Zn] (SOD1)(X53S)
  • 货号：
    CSB-EP819871DO
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    SOD1
  • Uniprot No.：
    Q8WNN6
  • 种属：
    Canis lupus familiaris (Dog) (Canis familiaris)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    22.8 kDa
  • 表达区域：
    1-153aa(X53S)
  • 氨基酸序列
    MEMKAVCVLKGQGPVEGTIHFVQKGSGPVVVSGTITGLTEGEHGFHVHQFEDSTQGCTSAGPHFNPLSKKHGGPKDQERHVGDLGNVTAGKDGVAIVSIEDSLIALSGDYSIIGRTMVVHEKRDDLGKGDNEESTQTGNAGSRLACGVIGIAQ
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    C-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

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SOD1 Proteins

靶点详情

  • 功能：
    Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
  • 基因功能参考文献：
    1. cold storage from 24 h prior to freezing resulted in a decrease in the superoxide dismutase (SOD) activity in the frozen-thawed sperm cells whereas the glucose peroxidase (GPX) activity and tROS levels were not affected. PMID: 23279517
    2. a genomic insertion in intron 2 of SOD1 was found during routine diagnostic testing for canine degenerative myelopathy PMID: 27917507
    3. The cyclic changes of SOD1 and GPx1 suggest that they may play important roles in endometrial physiology, probably in apoptosis and proliferation. PMID: 27114170
    4. Variants within the SP110 nuclear body protein modify risk of canine degenerative myelopathy PMID: 27185954
    5. The results of this study support the hypothesis that the cytoplasmic accumulation and aggregate formation of the mutant SOD1 protein PMID: 26162235
    6. The SOD1:c.118G>A mutation could be a useful marker for breeding strategies intending to reduce the incidence of Degenerative myelopathy . PMID: 24390315
    7. The frequency of the canine degenerative myelopathy-associated c.118G>A (p.E40K) mutation of SOD1 in healthy Pembroke Welsh Corgis in Japan using conventional and real time PCR methods is reported. PMID: 23328634
    8. Our findings lend strong biochemical support to the toxic role of SOD1 in canine degenerative myelopathy and establish close parallels for the role mutant SOD1 plays in both canine and human disorders. PMID: 23707216
    9. Muscle and peripheral nerve specimens at varying disease stages from Pembroke Welsh Corgis and Boxers are homozygous for the SOD1 mutation and have spinal cord histopathology consistent with degenerative myelopathy. PMID: 22542607
    10. case report of c.52A > T missense mutation resulting in degenerative myelopathy PMID: 21848967
    11. the continuous expression of mutant SOD1 causes the downregulation of GLT-1 by increasing the internalisation and degradation of the surface transporter, and the cytosolic tail of GLT-1 is required to targets the transporter to degradation PMID: 15466883

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Cu-Zn superoxide dismutase family
  • 数据库链接：

    KEGG: cfa:403559

    UniGene: Cfa.6360

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