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  4. Recombinant Dog Nitric oxide synthase, inducible (NOS2), partial

Recombinant Dog Nitric oxide synthase, inducible (NOS2), partial

  • 中文名称：
    熟悉的犬NOS2重组蛋白
  • 货号：
    CSB-YP015943DO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    熟悉的犬NOS2重组蛋白
  • 货号：
    CSB-EP015943DO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    熟悉的犬NOS2重组蛋白
  • 货号：
    CSB-EP015943DO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    熟悉的犬NOS2重组蛋白
  • 货号：
    CSB-BP015943DO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    熟悉的犬NOS2重组蛋白
  • 货号：
    CSB-MP015943DO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NOS2
  • Uniprot No.：
    O62699
  • 别名：
    NOS2; Nitric oxide synthase; inducible; EC 1.14.13.39; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2
  • 种属：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8.
  • 基因功能参考文献：
    1. Increased iNOS, COX-2 and VEGF gene mRNA levels were found to be related with the histological grade of malignancy in dogs with mammary tumours. PMID: 28956485
    2. demonstrate for the first time that PPS is a novel inhibitor of IL-1beta-induced iNOS, c-Jun, and HIF-1alpha mRNA upregulation and iNOS protein induction which may be beneficial for prevention and treatment OA PMID: 28472120
    3. IL-17A gene transcription level was positively correlated with mRNA expression for iNOS and IFN-gamma PMID: 26590047
    4. Fatal outcome from pulmonary hemorrhages in dogs with leptospirosis was associated with low TNF-alpha, high IL-1beta, and high iNOS expression. PMID: 26824356
    5. A positive correlation was found between the number of iNOS cells in lymph nodes and interferon-gamma levels, and there was a negative correlation between parasites and iNOS cell densities both in lymph nodes and spleen. PMID: 25195062
    6. results showed that the median expression of iNOS was higher in symptomatic dogs and oligosymptomatic dogs compared to non-infected dogs PMID: 21188604
    7. Chronic non-ischaemic heart failure results in atrial oxidative stress and electrophysiologic abnormalities by depletion of tetrahydrobiopterin and uncoupling of NOS2. PMID: 21460065
    8. Inflammatory cytokines and NO form INOS may be involved in intraneural inflammatory changes arising from mechanical compression PMID: 16022989
    9. treatment with avocado/soybean unsaponifiables can reduce the development of early osteoarthritic cartilage and subchondral bone lesions. This effect appears to be mediated through the inhibition of inducible nitric oxide synthase and MMP-13 PMID: 19291317

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  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    NOS family
  • 数据库链接：

    KEGG: cfa:403822

    UniGene: Cfa.45041

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