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  4. Recombinant Dog Calsequestrin-2 (CASQ2)

Recombinant Dog Calsequestrin-2 (CASQ2)

  • 中文名称：
    Recombinant Dog Calsequestrin-2(CASQ2)
  • 货号：
    CSB-YP004557DO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Dog Calsequestrin-2(CASQ2)
  • 货号：
    CSB-EP004557DO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Dog Calsequestrin-2(CASQ2)
  • 货号：
    CSB-EP004557DO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Dog Calsequestrin-2(CASQ2)
  • 货号：
    CSB-BP004557DO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Dog Calsequestrin-2(CASQ2)
  • 货号：
    CSB-MP004557DO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CASQ2
  • Uniprot No.：
    P12637
  • 别名：
    CASQ2Calsequestrin-2; Calsequestrin; cardiac muscle isoform
  • 种属：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-410
  • 氨基酸序列
    E EGLNFPTYDG KDRVVSLTEK NFKQVLKKYD VLCLYYHESV SSDKVAQKQF QLKEIVLELV AQVLEHKDIG FVMVDAKKEA KLAKKLGFDE EGSLYVLKGD RTIEFDGEFA ADVLVEFLLD LIEDPVEIIN SKLEVQAFER IEDQIKLIGF FKSEESEYYK AFEEAAEHFQ PYIKFFATFD KGVAKKLSLK MNEVDFYEPF MDEPIAIPDK PYTEEELVEF VKEHQRPTLR RLRPEDMFET WEDDLNGIHI VAFAERSDPD GYEFLEILKQ VARDNTDNPD LSIVWIDPDD FPLLVAYWEK TFKIDLFKPQ IGVVNVTDAD SVWMEIPDDD DLPTAEELED WIEDVLSGKI NTEDDDNEEG DDGDDDEDDD DDDGNNSDEE SNDDSDDDDE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
  • 基因功能参考文献：
    1. Processing of CSQ2 may be an adaptive response to the myocardium under stresses that are capable of inducing heart failure. PMID: 23456435
    2. CASQ2. The arrhythmogenic CASQ2(D307H) mutation impairs SR Ca2+ storing & release & destabilizes the Ca2+-induced Ca2+ release mechanism by reducing Ca2+ buffering in the SR and/or by altering the responsiveness of the release channel to luminal Ca2+. PMID: 14715535
    3. there are undesirable and damaging interactions between canine calsequestrins and tricyclic antidepressants, phenothiazine derivatives, anthracyclines, and many other pharmaceutical compounds. PMID: 15492117
  • 亚细胞定位：
    Sarcoplasmic reticulum lumen.
  • 蛋白家族：
    Calsequestrin family
  • 组织特异性：
    Detected in heart muscle (at protein level).
  • 数据库链接：

    KEGG: cfa:483134

    STRING: 9615.ENSCAFP00000014348

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