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  4. Recombinant Danio rerio Mast/stem cell growth factor receptor kita (kita), partial

Recombinant Danio rerio Mast/stem cell growth factor receptor kita (kita), partial

  • 中文名称：
    斑马鱼kita重组蛋白
  • 货号：
    CSB-YP810329DIL
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    斑马鱼kita重组蛋白
  • 货号：
    CSB-EP810329DIL
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    斑马鱼kita重组蛋白
  • 货号：
    CSB-EP810329DIL-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    斑马鱼kita重组蛋白
  • 货号：
    CSB-BP810329DIL
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    斑马鱼kita重组蛋白
  • 货号：
    CSB-MP810329DIL
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    kita
  • Uniprot No.：
    Q8JFR5
  • 别名：
    kita; kit; sparse; Mast/stem cell growth factor receptor kita; SCFR; EC 2.7.10.1; Tyrosine-protein kinase Kit
  • 种属：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine kitlg/scf and plays a role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, and in mast cell development, migration and function. Required for the migration of cells in the melanocyte lineage and the survival of embryonic melanocytes. Required for the differentiation of some, but not all, melanocytes. Not essential for hematopoiesis or primordial germ cell development.
  • 基因功能参考文献：
    1. The expression of c-kit and beta-catenin suggests that erythropoietin may exert a role in regeneration reducing the extent of tubular damage from the outset after gentamicin administration. PMID: 27679401
    2. strong evidence for a Kit-mediated bi-directional communication system in the zebrafish ovarian follicle PMID: 23409152
    3. The role of ErbB and Kit signalling in establishing melanophore stem cells in zebrafish. PMID: 23364329
    4. The regeneration defect in kita mutants is not due to defects in melanocyte stem cells recruitment or in the proliferation, differentiation or survival of the daughter cells, but is instead due to a defect in stem cell establishment. PMID: 23364331
    5. Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish PMID: 21170325
    6. melanocyte changes its response to Kit receptor signaling and function during development, first to promote migration, then to promote survival through distinct Kit-dependent mechanisms. PMID: 14512025
    7. kit is required for melanocyte differentiation in zebrafish when melanoblast development is delayed. PMID: 15300437
    8. Ectopic expression of foxd3 indicates that foxd3 promotes early melanophore death only when kit is inactive PMID: 19301400

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily
  • 组织特异性：
    Expressed in cells of the neural crest-melanocyte lineage. In the embryo, also expressed in mesodermal cells that give rise to hematopoietic precursors, notochord, neural crest-derived cells of the branchial arches, pineal gland, retina and mechanorecepti
  • 数据库链接：

    KEGG: dre:30256

    STRING: 7955.ENSDARP00000099069

    UniGene: Dr.81312

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