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  4. Recombinant Danio rerio Cadherin-2 (cdh2), partial

Recombinant Danio rerio Cadherin-2 (cdh2), partial

  • 中文名称：
    Recombinant Danio rerio Cadherin-2(cdh2) ,partial
  • 货号：
    CSB-YP856174DIL
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Danio rerio Cadherin-2(cdh2) ,partial
  • 货号：
    CSB-EP856174DIL
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Danio rerio Cadherin-2(cdh2) ,partial
  • 货号：
    CSB-EP856174DIL-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Danio rerio Cadherin-2(cdh2) ,partial
  • 货号：
    CSB-BP856174DIL
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Danio rerio Cadherin-2(cdh2) ,partial
  • 货号：
    CSB-MP856174DIL
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    cdh2
  • Uniprot No.：
    Q90275
  • 别名：
    cdh2; pacCadherin-2; Neural cadherin; N-cadherin; Parachute; ZNCAD
  • 种属：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain.
  • 基因功能参考文献：
    1. N-cadherin is involved in neuronal activity-dependent regulation of myelinating capacity of zebrafish individual oligodendrocytes in vivo. PMID: 27771903
    2. N-cadherin-defective endodermal cells resembled ectodermal cells; expression of N-cadherin sufficient to induce internalization of ectodermal cells PMID: 28874564
    3. In zebrafish, E-cadherin is expressed in lens epithelium, whereas N-cadherin is required for lens fiber growth PMID: 28196805
    4. Newly synthesized N-cadherin molecules move from the lateral to the basal surface of cardiomyocytes during trabeculation. This localization requires Erbb2 signaling. PMID: 27339140
    5. Throughout somitogenesis, Cadherin2 promotes extracellular matrix (ECM) assembly along tissue boundaries and inhibits ECM assembly in the tissue mesenchyme. PMID: 26853361
    6. Cdon is required to localize N-cadherin to the cell membrane in migratory neural crest cells for directed migration. PMID: 26256768
    7. shows that a dominant-negative nuclear localization mutant of Sox3 can cause ectopic expression of organizer genes via a mechanism that activates all of these earlier factors, resulting in later axis duplication including major bifurcations of the CNS. PMID: 20610482
    8. Genetic suppression of N-cadherin function interferes with basal migration of retinal progenitors and subsequent regeneration of HuC/D(+) inner retinal neurons. PMID: 24154521
    9. N-cadherin deficiency in Danio does not prevent the first tooth from starting to develop, but stops its development at the early cytodifferentiation stage and completely inhibits the development of the other first-generation teeth. PMID: 23396519
    10. N-cadherin regulates motor axon growth and branching without severely affecting the mechanisms that control axonal target selection. PMID: 21452216
    11. Slit-Robo signaling downregulates N-cadherin activity to allow apical retraction in newly generated retinal ganglion cells. PMID: 22219284
    12. demonstration of a novel mechanism of cell adhesion, mediated by a complex of Protocadherin-19 (Pcdh19) and N-cadherin (Ncad) PMID: 22184198
    13. zebrafish N-cadherin restricts cell proliferation in the dorsal region of the neural tube by regulating cell-cycle length. PMID: 21389116
    14. Protocadherin-19 and N-cadherin interact to control cell movements during anterior neurulation PMID: 21115806
    15. the ratio of the number of cells undergoing neurogenic cell division to the total number of cells undergoing mitosis was decreased in retinas of n-cadherin knockout zebrafish. PMID: 20362667
    16. Cadherin-2 plays a key role during zebrafish granule cell migration by continuously coordinating cell-cell contacts and cell polarity through the remodeling of adherens junctions. PMID: 19901980
    17. Both Cdh2 and Cdh4 immunoreactivities were specifically up-regulated in regenerating retina and/or the optic pathway and both may be important for regeneration of injured retinal ganglion cell axons PMID: 12429186
    18. cell adhesion mediated by N-cadherin is of major importance for retinal lamination and involved in maintenance of the lens epithelial sheet, but is not essential for the formation of photoreceptor ultrastructure or for synaptogenesis. PMID: 12619142
    19. has several distinct and crucial functions during the establishment of retinal organization PMID: 12702661
    20. Zebrafish N-cadherin, encoded by the glass onion locus, plays an essential role in retinal patterning. PMID: 12812791
    21. analyzed expression patterns of three zebrafish classical (type I) cadherins (cadherin-1, -2, and -4) in the embryonic zebrafish cranial ganglia and lateral line system PMID: 12972001
    22. cadherin-2 is crucial for the normal development of the zebrafish pectoral fins PMID: 14648850
    23. Dynamic and reciprocal waves of N-cadherin and M-cadherin expression within the myotome, which correlate precisely with cell migration, generate differential adhesive environments that drive slow-twitch muscle cell migration through the myotome. PMID: 14667409
    24. cadherin-2 function is crucial for the normal formation of the zebrafish lateral line system and a subset of cranial ganglia PMID: 15108318
    25. To investigate N-cadherin dynamics in developing axons, we used in vivo two-photon time-lapse microscopy of N-cadherin--green fluorescent protein (Ncad-GFP), which was expressed in Rohon-Beard neurons of the embryonic zebrafish spinal cord PMID: 15483121
    26. myocardiocyte differentiation and physiological cardiovascular performance is impaired when cadherin2 function is disrupted. PMID: 16719917
    27. We address the mechanisms underlying anterior neural tube morphogenesis in the zebrafish and the role of the cell adhesion molecule N-cadherin (N-cad) in this process. PMID: 16943271
    28. N-cadherin is essential for morphogenesis of the mesodermal germ layer during gastrulation. PMID: 17826762
    29. N-cadherin and other members of the classical cadherin subfamily function in parallel with the planar cell polarity pathway to shape the posterior axis during post-gastrulation stages PMID: 18045497
    30. data reveal a novel role for cdh2 in the establishment of circuits by peripheral sensory neurons PMID: 19356698
    31. N-cadherin stabilizes pre- to postsynaptic contacts early in synapse development, suggesting that regulated cleavage of the N-cadherin prodomain is a mechanism by which the kinetics of synaptogenesis are regulated. PMID: 19365814

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expression in the embryo is initially found in all deep cells but later becomes restricted to various epithelial and neuronal tissues. Found in discrete areas of cell-cell adhesion when epiboly is nearly completed. Expressed in adult brain, eyes and trunk
  • 数据库链接：

    KEGG: dre:30291

    STRING: 7955.ENSDARP00000003949

    UniGene: Dr.75081

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