Recombinant Chicken Retinoblastoma-associated protein (RB1), partial

中文名称：

鸡RB1重组蛋白
货号：

CSB-YP856183CH
规格：
来源：

Yeast
其他：

中文名称：

鸡RB1重组蛋白
货号：

CSB-EP856183CH
规格：
来源：

E.coli
其他：

中文名称：

鸡RB1重组蛋白
货号：

CSB-EP856183CH-B
规格：
来源：

E.coli
共轭：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名称：

鸡RB1重组蛋白
货号：

CSB-BP856183CH
规格：
来源：

Baculovirus
其他：

中文名称：

鸡RB1重组蛋白
货号：

CSB-MP856183CH
规格：
来源：

Mammalian cell
其他：

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纯度：

>85% (SDS-PAGE)
基因名：

RB1
Uniprot No.：

Q90600
别名：

RB1; Retinoblastoma-associated protein; p104; pRb; Rb
种属：

Gallus gallus (Chicken)
蛋白长度：

Partial
蛋白标签：

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
产品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
复溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
储存条件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保质期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
货期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事项：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

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功能：

Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle. The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes. Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription. Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase. RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C.
基因功能参考文献：
1. Experiments showed an essential role of pRb in S-phase entry of the supporting cells in the damaged neonatal chicken utricle and have shown that the proliferation of these cells requires the phosphorylation of pRb PMID: 25100553
2. the RB1 gene was a major gene for body weight and bone traits PMID: 21906182
亚细胞定位：

Nucleus.
蛋白家族：

Retinoblastoma protein (RB) family
数据库链接：

KEGG: gga:386582

STRING: 9031.ENSGALP00000035706

UniGene: Gga.2986

Recombinant Chicken Retinoblastoma-associated protein (RB1), partial

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