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  4. Recombinant Chicken Netrin-1 (NTN1), partial

Recombinant Chicken Netrin-1 (NTN1), partial

  • 中文名称：
    鸡NTN1重组蛋白
  • 货号：
    CSB-YP841913CH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    鸡NTN1重组蛋白
  • 货号：
    CSB-EP841913CH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    鸡NTN1重组蛋白
  • 货号：
    CSB-EP841913CH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    鸡NTN1重组蛋白
  • 货号：
    CSB-BP841913CH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    鸡NTN1重组蛋白
  • 货号：
    CSB-MP841913CH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NTN1
  • Uniprot No.：
    Q90922
  • 别名：
    NTN1Netrin-1
  • 种属：
    Gallus gallus (Chicken)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Netrins control guidance of CNS commissural axons and peripheral motor axons. Promotes neurite outgrowth from commissural axons but acts as a chemorepellent for trochlear motor axons. These effects are mediated by distinct receptors.
  • 基因功能参考文献：
    1. Ntn1 may play divergent cellular roles despite its conserved expression during canal morphogenesis in chicken and mouse. PMID: 28851705
    2. Data suggest that, in response to netrin-1/netrin receptor (DCC) signaling, p120RasGAP is recruited to growth cones and supports axon outgrowth; p120RasGAP Src homology 2 domains exhibit scaffolding properties sufficient to support axon outgrowth. PMID: 26710849
    3. Netrin-1 and integrins interact on growth cones; netrin-1 causes integrin activation PMID: 24001590
    4. Proximal tubular epithelial cells may play a prominent role in interstitial fibrosis and that netrin-1 could be a useful therapeutic agent for treating kidney fibrosis. PMID: 23408169
    5. Netrin-1-induced suppression of prostaglandin E2 production was mediated through suppression of NFkappaB-mediated cyclooxygenase-2 (COX-2) in renal tubular epithelial cells. PMID: 23041393
    6. Study shows acute treatment with two attractive guidance cues, NGF and netrin-1, for embryonic dorsal root ganglion and temporal retinal neurons, respectively, results in increased growth cone membrane protrusion, actin polymerization, and F-actin. PMID: 20506164
    7. These results provide evidence that netrin 1 acts as chemoattractant to migrating GnRH neurons at the dorsocaudal part of the septum and has the potential to regulate the ventral migration of GnRH neurons to the ventral septum and the preoptic area. PMID: 20394056
    8. Netrin binds through multiple domains to both DCC and Unc5c. PMID: 15574733
    9. Netrin-1 raises the frequency of repetitive Ca2+ transients. This involve release from intracellular stores. Ca2+ signaling is essential for netrin-1-induced axon branching. CaMKII & MAPK are the major downstream targets & are needed for axon branching. PMID: 16014732
    10. Data show that Netrin-1 expressing cells inhibited angiogenic sprouting of unc5b expressing blood vessels, but had no pro-angiogenic activity at any stage of development examined. PMID: 18439993
    11. netrin-1 protects renal tubular epithelial cells against ischemia reperfusion-induced injury by increasing proliferation and suppressing apoptosis PMID: 19700747

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  • 亚细胞定位：
    Secreted. Cytoplasm.
  • 数据库链接：

    KEGG: gga:396389

    STRING: 9031.ENSGALP00000038541

    UniGene: Gga.794

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