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  4. Recombinant Caenorhabditis elegans Dual oxidase 1 (bli-3), partial

Recombinant Caenorhabditis elegans Dual oxidase 1 (bli-3), partial

  • 中文名称：
    Recombinant Caenorhabditis elegans Dual oxidase 1(bli-3) ,partial
  • 货号：
    CSB-YP007228CXY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Caenorhabditis elegans Dual oxidase 1(bli-3) ,partial
  • 货号：
    CSB-EP007228CXY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Caenorhabditis elegans Dual oxidase 1(bli-3) ,partial
  • 货号：
    CSB-EP007228CXY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Caenorhabditis elegans Dual oxidase 1(bli-3) ,partial
  • 货号：
    CSB-BP007228CXY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Caenorhabditis elegans Dual oxidase 1(bli-3) ,partial
  • 货号：
    CSB-MP007228CXY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    bli-3
  • Uniprot No.：
    O61213
  • 别名：
    bli-3; F56C11.1Dual oxidase 1; DUOX1; EC 1.11.1.-; EC 1.6.3.1; Blistered cuticle protein 3; NADPH thyroid oxidase 1
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in cuticle biogenesis. In complex with doxa-1 and tsp-15, produces reactive oxygen species (ROS), which are probably used by mlt-7 for tyrosine cross-linking, thus stabilizing cuticular extracellular matrix. May regulate the production of ROS by playing a role in modulating proline catabolism. Required in combination with mlt-7 for correct formation of cross-links in cuticle collagens. Association with the GTPase rho-1 promotes ROS production and this interaction may be modulated by memo-1, in order to control the oxidative stress response and longevity.
  • 基因功能参考文献：
    1. Here, the authors identified the Caenorhabditis elegans orthologue of mammalian mediator of ErbB2-driven cell motility, MEMO-1, as a protein that inhibits BLI-3/NADPH oxidase. PMID: 28085666
    2. proline catabolism governs reactive oxygen species (ROS) homeostasis and subsequent activation of SKN-1, a critical transcription factor regulating xenobiotic stress response and pathogen defense. Intriguingly, proline catabolism-mediated activation of SKN-1 requires cell-membrane dual-oxidase Ce-Duox1/BLI-3, highlighting the importance of interaction between mitochondrial and cell-membrane components in host defense. PMID: 27974198
    3. BLI-3/TSP-15/DOXA-1 dual oxidase complex is required for the toxic pleiotropic effects of excess iodide. PMID: 25480962
    4. We demonstrated that TSP-15, BLI-3, and DOXA-1 form complexes in vitro and in vivo. Cell-fusion-based analysis suggested that association with TSP-15 at the cell surface is crucial for BLI-3 activation to release H(2)O(2). PMID: 23028364
    5. ROS generation by Ce-Duox1/BLI-3 activates a protective SKN-1 response via p38 MAPK signaling. PMID: 22216003
    6. study of mutations of the DUOX1 truncated peroxidase domain to investigate possible role of the distal tyrosyl residue in heme binding; result argues that the DUOX peroxidase domain is primarily responsible for tyrosine cross-linking PMID: 20947510
    7. Extracellular dopamine potentiates kanganese-induced oxidative stress, lifespan reduction, and neurodegeneration in a BLI-3-dependent manner. PMID: 20865164
    8. Yeast mutants sod1Delta and yap1Delta fail to cause disease except in bli-3 worms which carry a mutation in a dual oxidase gene. PMID: 19502579

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Peroxidase family
  • 组织特异性：
    Expressed in hypodermal cells.
  • 数据库链接：

    KEGG: cel:CELE_F56C11.1

    STRING: 6239.F56C11.1

    UniGene: Cel.31857

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