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  4. Recombinant Bovine herpesvirus 1.1 E3 ubiquitin-protein ligase ICP0 (BICP0), partial

Recombinant Bovine herpesvirus 1.1 E3 ubiquitin-protein ligase ICP0 (BICP0), partial

  • 中文名称：
    Recombinant Bovine herpesvirus 1.1 E3 ubiquitin-protein ligase ICP0(BICP0) ,partial
  • 货号：
    CSB-YP335440BJT
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Bovine herpesvirus 1.1 E3 ubiquitin-protein ligase ICP0(BICP0) ,partial
  • 货号：
    CSB-EP335440BJT
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Bovine herpesvirus 1.1 E3 ubiquitin-protein ligase ICP0(BICP0) ,partial
  • 货号：
    CSB-EP335440BJT-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Bovine herpesvirus 1.1 E3 ubiquitin-protein ligase ICP0(BICP0) ,partial
  • 货号：
    CSB-BP335440BJT
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Bovine herpesvirus 1.1 E3 ubiquitin-protein ligase ICP0(BICP0) ,partial
  • 货号：
    CSB-MP335440BJT
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    BICP0
  • Uniprot No.：
    P29128
  • 别名：
    BICP0; E3 ubiquitin-protein ligase ICP0; EC 2.3.2.27; IER 2.9/ER2.6; P135 protein; RING-type E3 ubiquitin transferase ICP0
  • 种属：
    Bovine herpesvirus 1.1 (strain Jura) (BoHV-1) (Infectious bovine rhinotracheitis virus)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Evades nuclear antiviral defenses triggered by dsDNA viruses. Acts during the initial stages of lytic infection and the reactivation of latent viral genome. Prevents the antiviral effect of nuclear bodies by degrading host PML and SP100.
  • 基因功能参考文献：
    1. VP16 and the promiscuous viral trans-activator (bICP0) are expressed during the escape from latency, suggesting they promote the production of infectious virus in a small subset of latently infected neurons. PMID: 23926348
    2. Bovine herpesvirus 1 protein bICP0 represses the transcription of bISG15 in fetal bovine lung cells. PMID: 22160940
    3. The authors demonstrate that bovine herpesvirus 1 bICP0 effectively inhibits bovine IFN-beta promoter activity and induces IRF3 degradation. PMID: 21689696
    4. Both miRNAs encoded within the bovine herpesvirus 1 latency-related gene were predicted to base pair with bICP0 mRNA sequences, suggesting that they reduce bICP0 levels. PMID: 20410286
    5. BICP0 functioning as an ubiquitin ligase, is a bona fide activator of the NF-kappaB signaling pathway. PMID: 15494213
    6. toxic functions of bICP0 correlate with caspase 3 cleavage and activation. PMID: 15557224
    7. contains several important functional domains: (i) the zinc RING finger, (ii) two separate domains that activate transcription, and (iii) a C-terminal nuclear localization signal that is also necessary for efficient transactivation. PMID: 15784882
    8. Mutations that disrupt the bICP0 zinc RING finger impair its ability to activate transcription, stimulate productive infection, inhibit interferon-dependent transcription in certain cell types and regulate subnuclear localization. PMID: 16760386
    9. ability of bICP0 to reduce interferon regulatory factor 3 protein levels is important with respect to disarming the interferon response during productive infection PMID: 17215277
    10. mutation of a single well-conserved cysteine residue in the C(3)HC(4) zinc RING finger of bICP0 has dramatic effects on the growth properties of bovine herpesvirus 1 PMID: 18842710
    11. The interaction between bICP0 and interferon regulatory factor 7 (IRF7) correlates with reduced trans-activation of the IFN-beta promoter by IRF7. PMID: 19176627
    12. The bICP0 gene also contains a novel early promoter that was activated by dexamethasone in mouse neuroblastoma cells. PMID: 19553330

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  • 蛋白家族：
    Simplexviruses ICp0 family
  • 数据库链接：

    KEGG: vg:1487364

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