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  4. Recombinant Bovine Toll-like receptor 4 (TLR4), partial

Recombinant Bovine Toll-like receptor 4 (TLR4), partial

  • 中文名称：
    牛TLR4重组蛋白
  • 货号：
    CSB-YP023603BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    牛TLR4重组蛋白
  • 货号：
    CSB-EP023603BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    牛TLR4重组蛋白
  • 货号：
    CSB-EP023603BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    牛TLR4重组蛋白
  • 货号：
    CSB-BP023603BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    牛TLR4重组蛋白
  • 货号：
    CSB-MP023603BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    TLR4
  • Uniprot No.：
    Q9GL65
  • 别名：
    TLR4; Toll-like receptor 4; EC 3.2.2.6; CD antigen CD284
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-). Activated by the signaling pathway regulator NMI which acts as damage-associated molecular patterns (DAMPs) in response to cell injury or pathogen invasion, therefore promoting nuclear factor NF-kappa-B activation.
  • 基因功能参考文献：
    1. PGE2 downregulates LPS-induced inflammatory responses via the TLR4-NF-kappaB signaling pathway in bovine endometrial epithelial cells. PMID: 29482767
    2. Based on the impact of both candidate genes,TLR4 and CACNA2D1, on udder health, linear or generalized linear mixed models was applied for testing the associations of SNPs located in the genes and clinical mastitis PMID: 29321363
    3. a single nucleotide polymorphism of the bovine toll like receptor 4 gene (TLR4) in New Zealand (NZ) Holstein-Friesian x Jersey (HF x J) cross dairy cows was associated with milk production traits PMID: 29154742
    4. STA3 facilitates TLR4-dependent IL-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells. PMID: 26813342
    5. Studied genetic diversity of the Toll-like receptor gene TLR4 in Czech Red and Czech Red Pied cattle. Found 8 SNPs, which were grouped into 18 haplotypes. PMID: 28489974
    6. TLR4 polymorphisms are associated with lower reproductive Performance. PMID: 28093679
    7. As a pilot study, the present results revealed that identified SNPs in IL8 and TLR4 genes can be used as a genetic marker and predisposing factor for resistance/susceptibility to digital dermatitis in dairy cows. However, TLR4 gene may be a potential candidate for such disease. PMID: 27813832
    8. Transcription levels of TLR2, TLR4, and CD14 in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum. PMID: 26777563
    9. Bovine viral diarrhea virus type 2 infection modulates TLR4 responsiveness in differentiated myeloid cells. PMID: 26043978
    10. TLR2 and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells. PMID: 26048276
    11. TLR4 polymorphisms are associated with susceptibility to Mycobacterium avium ssp. paratuberculosis infection in Holsteins PMID: 26360329
    12. positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 with the formation of NETs and change in surface architecture. PMID: 24915786
    13. Studied SNPs in the bovine toll-like receptor 4 (TLR4) and monocyte chemo attractant protein-1(CCL2) genes. PMID: 24813219
    14. Studied bovine TLR4 gene in mastitis resistance by association as well as expression profiling analysis in crossbred cattle. PMID: 24669869
    15. Findings indicate that intervertebral disc (IVD) cells constitutively express TLR4. PMID: 22850250
    16. Data suggest that granulosa cells from dominant follicles express functional TLR2 and TLR4; granulosa cells appear to participate in innate immunity by responding to bacterial lipopolysaccharides/lipopeptides via TLR2 and TLR4 signaling pathways. PMID: 23825132
    17. The expressions of host TLR2 and 4 genes were significantly higher in acidosis-resistant steers compared to those in acidosis-susceptible steers. PMID: 22622335
    18. TLR4 and downstream adaptor molecules, transcription factors and cytokines were up-regulated when endometrial epithelial cells were stimulated with LPS PMID: 23218938
    19. Data from an in vitro co-culture model suggest that an early response of endometrium in uterine infection is up-regulation of expression of TLR4 and CD14 (monocyte differentiation antigen CD14). PMID: 23077171
    20. bovine granulosa cells initiate an innate immune response to LPS via the TLR4 pathway, leading to inflammation and to perturbation of meiotic competence PMID: 21990308
    21. In the case of the TLR4 gene, 3 tightly linked SNP were found to be associated with susceptibility to M. avium ssp. paratuberculosis infection. PMID: 21700053
    22. the Int1 (A/G) SNP had a significant effect on infectious bovine keratoconjunctivitis infection rates both in-season (P < 0.05) and at weaning (P < 0.01) PMID: 20938658
    23. ALOX5AP, CPNE3, IL1R2, IL6, TLR2, TLR4, and THY1 were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows. PMID: 20072847
    24. fine mapping of bovine toll-like receptor 4 and toll-like receptor 2 regions PMID: 12584610
    25. data provide a basic understanding of TLR4 sequence variation and supply haplotypes markers for disease association studies PMID: 12915733
    26. Direct mouse mammary tumor virus binding to TLR4 induced maturation of bone marrow-derived dendritic cells and up-regulated expression of the MMTV entry receptor (CD71) on these cells PMID: 14694089
    27. mRNA abundances of TLR9, TLR2, and TLR4 together with those of beta-defensin 5 (BNBD5), an early bactericidal effector molecule of the innate system, in healthy and infected mammary glands PMID: 14715566
    28. similarity in TLR4 staining in macrophages, epithelium and vascular endothelium among dog, pig and cattle PMID: 15375763
    29. Toll-like receptor 4 mRNA and CD14 mRNA and protein were detected in bovine endometrial stromal and epithelial cells by RT-PCR and flow cytometry. PMID: 16223858
    30. Single nucleotide polymorphisms in promotor region P-226 and in exon3 were found to be associated with estimated breeding values for lactation persistency and somatic cell scores in Canadian Holstein bull population PMID: 16899698
    31. Polymorphism was detected in three Chinese populations of cattles with mastitis. PMID: 17138537
    32. Results showed that both alleles (A and B) of two loci were found in all the three populations of cattles with mastitis and the value of polymorphism information content (PIC) indicated that these were a moderate polymorphism in TLR4. PMID: 17560526
    33. both S. aureus and E. coli pathogens activate equally well bovine TLR2 and TLR4 receptors to induce NF-kappaB activation PMID: 17936907
    34. The upregulation of TLR4 by lipopolysaccharides may indicate a positive adaptation by mammary epithelial cells to effectively respond to different types of mastitis pathogens. PMID: 18096120
    35. A combined linkage and linkage disequilibrium method was used to investigate possible associations between the TLR2 and THR4 genes and mastitis susceptibility recorded in the Norwegian Red cattle population. PMID: 18363976
    36. results indicate that the c.-226C>G SNP affects the expression of TLR4, suggesting that this SNP might be influencing the binding and interaction of transcription factors regulating gene expression PMID: 18817322
    37. A tendency toward statistical significance for the effect of polymorphisms in the odds of infection in cattle was not found for alleles TLR4. PMID: 19525022

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Early endosome. Cell projection, ruffle.
  • 蛋白家族：
    Toll-like receptor family
  • 数据库链接：

    KEGG: bta:281536

    STRING: 9913.ENSBTAP00000008190

    UniGene: Bt.9030

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