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  4. Recombinant Bovine Secretogranin-1 (CHGB), partial

Recombinant Bovine Secretogranin-1 (CHGB), partial

  • 中文名称：
    Recombinant Bovine Secretogranin-1(CHGB) ,partial
  • 货号：
    CSB-YP005345BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Bovine Secretogranin-1(CHGB) ,partial
  • 货号：
    CSB-EP005345BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Bovine Secretogranin-1(CHGB) ,partial
  • 货号：
    CSB-EP005345BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Bovine Secretogranin-1(CHGB) ,partial
  • 货号：
    CSB-BP005345BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Bovine Secretogranin-1(CHGB) ,partial
  • 货号：
    CSB-MP005345BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CHGB
  • Uniprot No.：
    P23389
  • 别名：
    CHGB; Secretogranin-1; Chromogranin-B; CgB; Secretogranin I; SgI) [Cleaved into: PE-11; Secretogranin-1(476-566); Peptide BAM-1745; Secretolytin; CCB peptide]
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. The 16 pairs of basic AA distributed throughout its sequence may be used as proteolytic cleavage sites.; Secretolytin has antibacterial activity.
  • 基因功能参考文献：
    1. chromogranin B has a role in the IP(3)-mediated Ca(2+) release mechanism of secretory granules PMID: 12438140
    2. CGB may play an important modulatory role in the control of Ca2+ release from the endoplasmic reticulum PMID: 14506248
    3. colocalization of all three inositol 1,4,5-trisphosphate receptor (IP(3)R)isoforms with chromogranin B to the extent that the majority of each IP(3)R isoform-labeling gold particles found in the nucleoplasm PMID: 15966749
    4. determination of the subcellular distribution of chromogranins A and B in chromaffin cells; results suggest that chromogranins are at the center of intracellular Ca(2+) homeostasis in secretory cells PMID: 16140299
    5. Chromogranin B was found to co-localize with secretogranin II and IP3 receptors in the nucleus, more specifically, in the IP3-sensitive nucleoplasmic Ca2+ store vesicles. PMID: 18020452

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  • 亚细胞定位：
    [Secretogranin-1]: Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Lumenal side. Note=Neuroendocrine and endocrine secretory granules. Found to be membrane bound inside the secretory vesicles. The N-terminal region exhibits pH-dependent membrane-binding activity, binds to the membrane at intravesicular pH (5.5) and freed when the pH is near to physiological pH.; [Peptide BAM-1745]: Secreted.; [Secretolytin]: Secreted.
  • 蛋白家族：
    Chromogranin/secretogranin protein family
  • 数据库链接：

    KEGG: bta:281071

    STRING: 9913.ENSBTAP00000015645

    UniGene: Bt.5448

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