Recombinant Bovine Osteocalcin (BGLAP)

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中文名称：

Recombinant Bovine Osteocalcin (BGLAP)
货号：

CSB-EP002682BO
规格：

￥1836
图片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

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纯度：

Greater than 95% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

BGLAP
Uniprot No.：

P02820
别名：

Bone Gla protein;BGP;Gamma-carboxyglutamic acid-containing protein
种属：

Bos taurus (Bovine)
蛋白长度：

Full Length of Mature Protein
来源：

E.coli
分子量：

21.0 kDa
表达区域：

52-100aa
氨基酸序列

YLDHWLGAPAPYPDPLEPKREVCELNPDCDELADHIGFQEAYRRFYGPV
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
蛋白标签：

N-terminal 6xHis-KSI-tagged
产品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
缓冲液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
复溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
储存条件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保质期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
货期：

3-7 business days
注意事项：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA：

Please contact us to get it.

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功能：

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
基因功能参考文献：
1. Osteopontin, osteocalcin and OB-cadherin expression in Synthetic nanohydroxyapatite vs bovine hydroxyapatite cultured Osteoblastic-like cells. PMID: 25316140
2. Data suggest that helical content of 3 Glu-OCN is 57% and is independent of calcium binding; 3 Glu-OCN contains 3 alpha-helices around a hydrophobic core; study includes first high-resolution structure of bovine 3 Glu-OCN using X-ray crystallography. PMID: 24138653
3. Serum osteocalcin levels in non-periparturient Holstein dairy cows were highest in the youngest cows, decreasing with age until time of first calving. In periparturient cows, serum osteocalcin levels were higher in primiparous than in multiparous cows. PMID: 21300389
4. Osteocalcin is released from the bone matrix during bone resorption as intact molecules and fragments; serum osteocalcin should be considered as a marker of bone turnover rather than bone formation PMID: 14970229
5. A molecular mechanism of lead toxicity for calcium binding proteins. PMID: 18793762
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亚细胞定位：

Secreted.
蛋白家族：

Osteocalcin/matrix Gla protein family
数据库链接：

KEGG: bta:281646

STRING: 9913.ENSBTAP00000047703

UniGene: Bt.4055

Recombinant Bovine Osteocalcin (BGLAP)

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