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  4. Recombinant Bovine Natural resistance-associated macrophage protein 1 (SLC11A1), partial

Recombinant Bovine Natural resistance-associated macrophage protein 1 (SLC11A1), partial

  • 中文名称：
    牛SLC11A1重组蛋白
  • 货号：
    CSB-YP632943BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    牛SLC11A1重组蛋白
  • 货号：
    CSB-EP632943BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    牛SLC11A1重组蛋白
  • 货号：
    CSB-EP632943BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    牛SLC11A1重组蛋白
  • 货号：
    CSB-BP632943BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    牛SLC11A1重组蛋白
  • 货号：
    CSB-MP632943BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC11A1
  • Uniprot No.：
    Q27981
  • 别名：
    SLC11A1; NRAMP1; Natural resistance-associated macrophage protein 1; NRAMP 1; Solute carrier family 11 member 1
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
  • 基因功能参考文献：
    1. SLC11A1 is a useful candidate gene related to tuberculosis in Chinese Holstein cattle. PMID: 28237028
    2. Polymorphisms in SLC11A1 and CXCR1 are significantly associated with bovine mastitis PMID: 26126595
    3. Analysis of allelic variants in the first and second microsatellite at the 3;UTR region of the SLC11A1 gene in cattle breeds present in Argentina. PMID: 23065223
    4. Preferential expression of SLC11A1 transcripts in gammadelta T cells is detected in bovine, human, and mouse gammadelta T cells. PMID: 23509347
    5. NRAMP1 consists of multiple targeting motifs for trafficking into lysosomes. PMID: 22382021
    6. DNA sequence analysis of NRAMP1 gene polymorphisms from 5 different cattle breeds PMID: 12499702
    7. Identification of a novel polymorphism within the bovine NRAMP 1 gene intron X. PMID: 15354350
    8. Study compared the frequency of Nramp1 3'UTR polymorphisms between Zebu and European bovine breeds. PMID: 16112749
    9. the present study demonstrated that the presence of (GT)(13) allele even in homozygous condition could not provide enough resistance to brucellosis in a naturally infected herd PMID: 16257497
    10. The expression of iNOS and NRAMP1 in the lymph nodes, lungs, and tuberculous granulomas in 8 bovine tuberculosis cases is reported. PMID: 16966449
    11. These results indicate that these polymorphisms at the NRAMP1 3'UTR do not affect resistance against B. abortus in cattle. PMID: 17353292
    12. Genotype of the SLC11A1 gene is associated with resistance to brucellosis. PMID: 18717968
    13. No associations were observed between the detected polymorphisms and somatic cell scores and milk yield in the Chinese Holstein population. PMID: 19070368
    14. Data suggested that Nramp1 may be a candidate gene responsible for mastitis in Holstein cattle. PMID: 19138902
    15. A tendency toward statistical significance for the effect of polymorphisms in the odds of infection in cattle was only found for alleles SLC11A1. PMID: 19525022

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    NRAMP family
  • 数据库链接：

    KEGG: bta:282470

    STRING: 9913.ENSBTAP00000020627

    UniGene: Bt.5373

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