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  4. Recombinant Bovine Kappa-casein (CSN3)

Recombinant Bovine Kappa-casein (CSN3)

  • 中文名称：
    Recombinant Bovine Kappa-casein(CSN3)
  • 货号：
    CSB-YP006064BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Bovine Kappa-casein(CSN3)
  • 货号：
    CSB-EP006064BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Bovine Kappa-casein(CSN3)
  • 货号：
    CSB-BP006064BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Bovine Kappa-casein(CSN3)
  • 货号：
    CSB-MP006064BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CSN3
  • Uniprot No.：
    P02668
  • 别名：
    CSN3; CSN10; CSNKKappa-casein [Cleaved into: Casoxin-C; Casoxin-6; Casoxin-A; Casoxin-B; Casoplatelin]
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-190
  • 氨基酸序列
    QEQNQEQPI RCEKDERFFS DKIAKYIPIQ YVLSRYPSYG LNYYQQKPVA LINNQFLPYP YYAKPAAVRS PAQILQWQVL SNTVPAKSCQ AQPTTMARHP HPHLSFMAIP PKKNQDKTEI PTINTIASGE PTSTPTTEAV ESTVATLEDS PEVIESPPEI NTVQVTSTAV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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CSN3 Proteins

靶点详情

  • 功能：
    Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.; Casoxins A, B and C have opioid antagonist activity. Casoxin C causes biphasic ileal contractions through the binding to the complement C3a receptors.; Casoplatelin inhibits platelet aggregation.
  • 基因功能参考文献：
    1. The influence of CSN3 genotype on milk production and chemical composition in Romanian Simmental cattle PMID: 28850632
    2. It was concluded that GH or IGF-I can independently promote the expression of CSN3 in bovine mammary epithelial cells in vitro. PMID: 26173981
    3. Statistical analysis established that the CSN3 gene has no statistically significant influence on daily milk, fat and protein yield and SCC PMID: 22614274
    4. Effects of beta-kappa-casein (CSN2-CSN3) haplotypes and BLG genotypes on yields were weak or trivial. PMID: 20655450
    5. the propensity of the disulfide-linked multimers to form fibrils is inversely related to their size, with monomeric kappa-casein being the most aggregation prone PMID: 20441567
    6. molecular dynamics simulation of bovine chymosin complexed with the P9-P70 residues of bovine kappa-casein PMID: 20155951
    7. Phe-Leu-Pro-Tyr-Pro-Tyr (FLPYPY), corresponding to peptidic sequence 76-81 of bovine kappa-casein, exhibits neurite outgrowth-stimulating activity over 10(-9) M PMID: 15618646
    8. The recombinant Caseinomacropeptide (hCMP)has been produced as a secretory product in yeast and was estimated to be 7.0kDa by SDS-PAGE, and showed a lower glycosylation than the natural bovine CMP. PMID: 15866733
    9. Findings suggest that alphaS- and beta-casein are potent inhibitors of kappa-casein fibril formation and may prevent large-scale fibril formation in vivo. PMID: 16363816
    10. kappa-casein gene (CSN3) promoter regions of cattle of different breeds revealed that 2 distinct haplotypes (A and B) exist at this locus with A allele dominant in all groups and B allele more representative of promoters from other ruminants PMID: 17699026
    11. The effect of lactoferrin on beta-casein and kappa-casein mRNA expression in mammospheres while silencing of LTF increased casein mRNA expression. PMID: 18226297
    12. In heterozygotes, beta-casein A and beta-lactoglobulin A were found at higher concentrations in milk compared with the variant encoded by the alternative allele whereas kappa-casein A and B variants were found at similar concentrations in AB heterozygotes PMID: 18363977
    13. These findings suggest a model of aggregation during which the S-carboxymethylated kappa-casein monomer is in rapid equilibrium with a micellar aggregate that subsequently undergoes a conformational rearrangement into a more organized species. PMID: 18616951
    14. The frequencies of the B allele of kappa-casein among breeds ranged from 0.01 to 0.30; the Sindhi breed had the highest frequency for the B allele (0.30), while the frequencies of this allele in other breeds ranged from 0.01 to 0.18. PMID: 18752189
    15. Six single nucleotide polymorphisms were identified and haplotype inference revealed 12 haplotypes, of which 8 were newly discovered PMID: 18765626

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Kappa-casein family
  • 组织特异性：
    Mammary gland specific. Secreted in milk.
  • 数据库链接：

    KEGG: bta:281728

    STRING: 9913.ENSBTAP00000028685

    UniGene: Bt.49421

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