Recombinant Bovine Insulin-like 3 (INSL3), partial

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中文名称：

牛INSL3重组蛋白
货号：

CSB-EP011747BO
规格：

￥1536
图片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

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纯度：

Greater than 90% as determined by SDS-PAGE.
基因名：

INSL3
Uniprot No.：

O77801
种属：

Bos taurus (Bovine)
蛋白长度：

Partial
来源：

E.coli
分子量：

20.1 kDa
表达区域：

22-66aa
氨基酸序列

GPAAAQEAPEKLCGHHFVRALVRLCGGPRWSSEEDGRPVAGGDRE
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
蛋白标签：

N-terminal 6xHis-KSI-tagged
产品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
缓冲液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
复溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
储存条件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保质期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
货期：

3-7 business days
注意事项：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

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功能：

Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.
基因功能参考文献：
1. These results suggest that reduced secretions of IGF-I, INSL3, and inhibin surrounding puberty may be associated with semen aberration in beef bulls. PMID: 29597124
2. These results suggested an acute regulation of INSL3 by luteinizing hormone (LH) because INSL3 concentrations increased immediately after endogenous and exogenous LH stimulation. PMID: 26318230
3. INSL3 plays a luteotropic role as a local regulator in the bovine corpus luteum. PMID: 23220928
4. BMP6 has a role in downregulating INSL3 and CYP17A1 and other proteins that modulate ovarian androgen production PMID: 23530236
5. The likely role of INSL3 as an important intrafollicular modulator of thecal interna cell function/steroidogenesis. PMID: 23546605
6. INSL3 provides the first example of a gender-specific fetal hormone with the potential to influence both placental and maternal physiology PMID: 21603619
7. relaxin-like factor mRNA was highly expressed in the corpus luteum on days 7 and 14 of pregnancy PMID: 15956752
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亚细胞定位：

Secreted.
蛋白家族：

Insulin family
组织特异性：

Expressed exclusively in Leydig cells of the testis.
数据库链接：

KEGG: bta:281870

STRING: 9913.ENSBTAP00000027848

UniGene: Bt.91145

Recombinant Bovine Insulin-like 3 (INSL3), partial

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