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  4. Recombinant Bovine Heparanase (HPSE)

Recombinant Bovine Heparanase (HPSE)

  • 中文名称：
    牛HPSE重组蛋白
  • 货号：
    CSB-YP010716BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    牛HPSE重组蛋白
  • 货号：
    CSB-EP010716BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    牛HPSE重组蛋白
  • 货号：
    CSB-EP010716BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    牛HPSE重组蛋白
  • 货号：
    CSB-BP010716BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    牛HPSE重组蛋白
  • 货号：
    CSB-MP010716BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HPSE
  • Uniprot No.：
    Q9MYY0
  • 别名：
    HPSE; Heparanase; EC 3.2.1.166) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit]
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    38-111
  • 氨基酸序列
    DDA AELEFFTERP LHLVSPAFLS FTIDANLATD PRFFTFLGSS KLRTLARGLA PAYLRFGGNK GDFLIFDPKK E
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. Essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans. Acts as procoagulant by enhancing the generation of activated factor X/F10 in the presence of tissue factor/TF and activated factor VII/F7. Independent of its enzymatic activity, increases cell adhesion to the extracellular matrix (ECM). Enhances AKT1/PKB phosphorylation, possibly via interaction with a lipid raft-resident receptor. Plays a role in the regulation of osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.
  • 基因功能参考文献：
    1. changing placental expression indicates possible involvement in fetomaternal communication and placental maturation PMID: 28864018
    2. Suggest that high glucose is a potent stimulator of endothelial heparanase secretion. PMID: 20164120
    3. Lutropin induces a transient increase in HPSE mRNA at specific times after its addition. PMID: 18818292
  • 亚细胞定位：
    Lysosome membrane; Peripheral membrane protein. Secreted. Nucleus.
  • 蛋白家族：
    Glycosyl hydrolase 79 family
  • 组织特异性：
    Highly expressed in placenta and weakly in the kidney, lung, spleen and uterus.
  • 数据库链接：

    KEGG: bta:281230

    STRING: 9913.ENSBTAP00000007550

    UniGene: Bt.8127

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