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  4. Recombinant Bovine Cytochrome c oxidase subunit 6A1, mitochondrial (COX6A1)

Recombinant Bovine Cytochrome c oxidase subunit 6A1, mitochondrial (COX6A1)

  • 中文名称：
    Recombinant Bovine Cytochrome c oxidase subunit 6A1, mitochondrial(COX6A1)
  • 货号：
    CSB-YP005847BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Bovine Cytochrome c oxidase subunit 6A1, mitochondrial(COX6A1)
  • 货号：
    CSB-EP005847BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Bovine Cytochrome c oxidase subunit 6A1, mitochondrial(COX6A1)
  • 货号：
    CSB-EP005847BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Bovine Cytochrome c oxidase subunit 6A1, mitochondrial(COX6A1)
  • 货号：
    CSB-BP005847BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Bovine Cytochrome c oxidase subunit 6A1, mitochondrial(COX6A1)
  • 货号：
    CSB-MP005847BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    COX6A1
  • Uniprot No.：
    P13182
  • 别名：
    COX6A1Cytochrome c oxidase subunit 6A1; mitochondrial; Cytochrome c oxidase polypeptide VIa-liver; Cytochrome c oxidase subunit SSG
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    25-109
  • 氨基酸序列
    SSGAHG EEGSARMWKA LTYFVALPGV GVSMLNVFLK SHHGEEERPE FVAYPHLRIR SKPFPWGDGN HTLFHNPHVN PLPTGYEDE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
  • 基因功能参考文献：
    1. After copper is reduced, electron transfer to oxidized heme a(3) is enhanced relative to the rate of entry of the first electron. PMID: 16704969
    2. photoreduction of oxidized bovine heart cytochrome c oxidase (CcO) by visible and UV radiation was investigated in the absence and presence of external reagents PMID: 16789843
    3. The calculations reported here show substantial protonation of Lys(I)-319 of cytochrome c oxidase at neutral pH once the stable X-ray crystallographic water molecule found immediately next to it is treated explicitly. PMID: 16843430
    4. X-ray structures of bovine heart cytochrome c oxidase at 1.8/1.9 A resolution in the oxidized/reduced states exhibit a redox coupled conformational change of an aspartate located near the intermembrane surface of the enzyme. PMID: 16904626
    5. The P(M)-->F transition of the catalytic cycle of cytochrome c oxidase from bovine heart was investigated using single-electron photoreduction and monitoring the subsequent events using spectroscopic and electometric techniques. PMID: 16938268
    6. Extended x-ray absorption spectroscopy analysis of Zn binding site(s) in bovine-heart cytochrome c oxidase and characterization of the inhibitory effect of internal zinc on respiratory activity and proton pumping reconstituted oxidase are presented. PMID: 17266955
    7. perturbation of an arginine guanidinium, probably Arg-438, lowers the energy of the transient charge-uncompensated electron-transfer intermediate by changing the charge distribution in response to heme-heme electron transfer PMID: 17302415
    8. analysis of the peroxidase activity of mitochondrial cytochrome c oxidase peroxidase activity PMID: 18021064
    9. The conserved glutamic acid 242 near the active site of CcO undergoes a protonation state-dependent conformational change, which provides a valve in the pumping mechanism. PMID: 18430799

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  • 亚细胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 蛋白家族：
    Cytochrome c oxidase subunit 6A family
  • 数据库链接：

    KEGG: bta:282199

    STRING: 9913.ENSBTAP00000016993

    UniGene: Bt.7193

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