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  4. Recombinant Bovine Collagen alpha-1 (II) chain (COL2A1), partial

Recombinant Bovine Collagen alpha-1 (II) chain (COL2A1), partial

  • 中文名称：
    Recombinant Bovine Collagen alpha-1(II) chain(COL2A1) ,partial
  • 货号：
    CSB-YP005739BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Bovine Collagen alpha-1(II) chain(COL2A1) ,partial
  • 货号：
    CSB-EP005739BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Bovine Collagen alpha-1(II) chain(COL2A1) ,partial
  • 货号：
    CSB-EP005739BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Bovine Collagen alpha-1(II) chain(COL2A1) ,partial
  • 货号：
    CSB-BP005739BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Bovine Collagen alpha-1(II) chain(COL2A1) ,partial
  • 货号：
    CSB-MP005739BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    COL2A1
  • Uniprot No.：
    P02459
  • 别名：
    COL2A1Collagen alpha-1(II) chain; Alpha-1 type II collagen
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
  • 基因功能参考文献：
    1. spontaneous missense mutation within COL2A1 in chondrodysplasia PMID: 29017490
    2. a first example of a dominant COL2A1 splice site variant as candidate causal mutation of a severe lethal chondrodysplasia phenotype PMID: 27296271
    3. Denaturation of the chimeric collagen increased its affinity for fibronectin, as seen for mammalian collagens. PMID: 24375478
    4. Two subsystems of meniscal collagen and their different thermal stabilities. PMID: 22773005
    5. Data show that expression of mRNAs for aggrecan, collagen type II, and versican were significantly effected by the intervention. PMID: 21289569
    6. Data show that biglycan, collagen type I, collagen type II, decorin, and versican were significantly affected by vibration duration, frequency, and amplitude. PMID: 20386503
    7. The distribution of type II and VI collagen was immunocytochemically investigated in bovine articular and nasal cartilage. PMID: 20213143
    8. Precisely the same conformational epitope constituted by the residues ARGLT on the three chains of the CII triple helix is recognized by the CB268 and CII-C1 mAbs. PMID: 15163538
    9. specific ADAMTS-2 domains cleave the aminopropeptide of fibrillar procollagens types I-III and V PMID: 16046392
    10. Changes in aggrecan and type II collagen promoter activity in transfected chondrocyte-laden cylindrical constructs were evaluated in response to a range of loading frequencies and durations. PMID: 16691412
    11. SMase down-regulates type II collagen in articular chondrocytes via activation of the ERK signaling cascade, redistribution of SOX9, and recruitment of c-Fos PMID: 18163502
    12. Response of the chondrocyte to a cryptic sequence of denaturated type II collagen may play a role in naturally occurring hypertrophy in endochondral ossification and in the development of cartilage pathology in osteoarthritis. PMID: 18589731
    13. IGF-I dose-dependently maintained cartilage formation PMID: 19214869

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Fibrillar collagen family
  • 数据库链接：

    KEGG: bta:407142

    STRING: 9913.ENSBTAP00000017505

    UniGene: Bt.21390

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