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  4. Recombinant Bovine Calpain-1 catalytic subunit (CAPN1), partial

Recombinant Bovine Calpain-1 catalytic subunit (CAPN1), partial

  • 中文名称：
    Recombinant Bovine Calpain-1 catalytic subunit(CAPN1) ,partial
  • 货号：
    CSB-YP632942BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Bovine Calpain-1 catalytic subunit(CAPN1) ,partial
  • 货号：
    CSB-EP632942BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Bovine Calpain-1 catalytic subunit(CAPN1) ,partial
  • 货号：
    CSB-EP632942BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Bovine Calpain-1 catalytic subunit(CAPN1) ,partial
  • 货号：
    CSB-BP632942BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Bovine Calpain-1 catalytic subunit(CAPN1) ,partial
  • 货号：
    CSB-MP632942BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CAPN1
  • Uniprot No.：
    Q27970
  • 别名：
    CAPN1Calpain-1 catalytic subunit; EC 3.4.22.52; Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; Calpain-1 large subunit; Micromolar-calpain; muCANP
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1.
  • 基因功能参考文献：
    1. Most heifer reproductive traits were not significantly affected by CAST and CAPN1 markers that are widely used to improve beef tenderness by selection and breeders should not be concerned with how these markers affect reproduction and other heifer traits with the possible exception of CAPN1 effects on calving date. PMID: 29448132
    2. study is the first report on genetic variant g.-1256 A>C in the promoter region of CAPN1 gene association with the semen quality of Chinese Holstein bulls by influencing its expression PMID: 27107033
    3. These results suggest an important role of genetics in meat color variation for cattle raised under the tropic conditions. PMID: 26946475
    4. This work is supportive of the importance of CAPN1 and CAST for mean tenderness in beef. PMID: 25414103
    5. Suppression of CANP1 resulted in the activation of caspase and heat-shock-protein systems which might in turn regulate apoptosis through the caspase-dependent cell death pathway. [CANP1] PMID: 23943438
    6. bovine CAPN-CAST interaction were well reflected in the geometry between the pharmacophore features and its shape constraints identified using our modeled bovine CAPN1/CAST4 complex structures PMID: 25215589
    7. This work confirms the importance of CAPN1 and CAST for tenderness in beef, provides a new effect of CAST on beef tenderness, and questions the utility of GHR as a selection marker for beef quality. PMID: 24398843
    8. It was found that the marker c.3379G > A in the CAPN1 gene influences the Ca content in the meat of this Nelore population, with the rare genotype associated with less Ca content. PMID: 23995697
    9. m- and micro-calpain immunosignals in the cytoplasm both along the Z disk/I band regions and in the form of intracellular stores. PMID: 23549461
    10. Association of polymorphisms in calpain 1, (mu/I) large subunit, calpastatin, and cathepsin D genes with meat quality traits in double-muscled Piemontese cattle. PMID: 22548449
    11. Relationships of the calpain system with meat tenderness and carcass traits were examined for 94 purebred Angus bulls. PMID: 21127989
    12. The association of polymorphisms in calpastatin and mu-calpain genes with meat tenderness in 3 French beef breeds is reported. PMID: 21178177
    13. A new insertion/deletion (InDel) polymorphism, consisting of a change of seven nucleotides for only one nucleotide (TCTGGGT --> C) within intron 17 of the CAPN1 gene, is reported. PMID: 20838904
    14. mu-calpain (CAPN1S) has a role in the proteolysis process and the meat tenderness of young cattle PMID: 20563650
    15. CAPN1 4751 affected all meat traits and CAPN1 316 showed association with tenderness and color. PMID: 20709460
    16. The mu-calpain gene marker improved beef tenderness without affecting other objective meat quality traits in heterozygous cattle compared with homozygotes for the unfavorable allele. PMID: 20495132
    17. The present study indicated that calpain-system gene markers are suitable for use in marker-assisted selection to improve meat tenderness in Brahman cattle without negative effects on other production and carcass characteristics. PMID: 20525933
    18. Single-nucleotide polymorphisms (SNPs) in the calpain (CAPN) and calpastatin (CAST) genes, described from Bos primigenius taurus, were examined to see if they were polymorphic in Nellore cattle. PMID: 20662159
    19. Reduced eNOS protein levels were accompanied by an increase in intracellular Ca(2+), augmented production of reactive oxygen species (ROS) and induction of Ca(2+)-dependent calpain activity. PMID: 18624772
    20. investigation of calpain 1 binding with alpha-actinin; propose that calpain 1 interacts in a resting state with cytoskeletal targets PMID: 14622253
    21. The utility of 2 variants of CAPN1 as markers for meat tenderness in U.S. bddf cattle is reported. PMID: 15537766
    22. Data show that calpain I is located at the periphery of the Z-band and at the midpoint of the I-band in skeletal muscle myofibrils. PMID: 15885106
    23. Data show that gamma-filamin formed a stable complex in vitro and in cells with calpain 1 in the absence of calcium stimulation. PMID: 16297652
    24. The mu-calpain-mediated proteolytic modification of TnT by removing the NH2-terminal variable region of TnT may act as an acute mechanism to adjust muscle contractility under stress conditions. PMID: 16981728
    25. direct measurement of epistatic interactions of causative mutations for quantitative trait loci (QTL) at calpain 1 (CAPN1), located on chromosome 29, with causative mutations for QTL variation at calpastatin (CAST), located on chromosome 7 PMID: 17603104
    26. Molecular association between mu-calpain and calpastatin in the mitochondria indicating that calpastatin could play an important role in preventing uncontrolled activity of mu-calpain. PMID: 17868638
    27. polymorphisms in CAPN1 might be one of the important genetic factors involved in carcass quality in beef cattle PMID: 18423040
    28. the protective effect exerted by HSP90 on eNOS degradation mediated by calpain represents a novel and critical mechanism that assures the reversibility of the intracellular trafficking and activation of the synthase PMID: 18682401
    29. A fragment (exon 8 to 10) of the CAPN1 gene was sequenced and genotyped in a sample of the main Spanish maternal beef breeds including Retinta, Morucha, and Avilena Negra-Iberica. PMID: 19544213

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  • 亚细胞定位：
    Cytoplasm. Cell membrane.
  • 蛋白家族：
    Peptidase C2 family
  • 数据库链接：

    KEGG: bta:281661

    STRING: 9913.ENSBTAP00000011678

    UniGene: Bt.252

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