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  4. Recombinant Bovine Aggrecan core protein (ACAN), partial

Recombinant Bovine Aggrecan core protein (ACAN), partial

  • 中文名称：
    Recombinant Bovine Aggrecan core protein(ACAN) ,partial
  • 货号：
    CSB-YP001130BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Bovine Aggrecan core protein(ACAN) ,partial
  • 货号：
    CSB-EP001130BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Bovine Aggrecan core protein(ACAN) ,partial
  • 货号：
    CSB-EP001130BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Bovine Aggrecan core protein(ACAN) ,partial
  • 货号：
    CSB-BP001130BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Bovine Aggrecan core protein(ACAN) ,partial
  • 货号：
    CSB-MP001130BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ACAN
  • Uniprot No.：
    P13608
  • 别名：
    ACAN; AGC1Aggrecan core protein; Cartilage-specific proteoglycan core protein; CSPCP
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.
  • 基因功能参考文献：
    1. the subsequent presentation of aggregan from ECM leads to CD4(+) T-cell activation and effector cell formation. PMID: 24032649
    2. Data show that expression of mRNAs for aggrecan, collagen type II, and versican were significantly effected by the intervention. PMID: 21289569
    3. The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (aggrecanase) explains the minor contribution of the MMP enzymes to aggrecan catabolism in vivo. PMID: 21055468
    4. Self-adhesion between highly negatively charged aggrecan macromolecules extracted from bovine cartilage extracellular matrix, was investigated. PMID: 21081100
    5. aggrecanase activity (a) is responsible for early TNFalpha-dependent aggrecan cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration. PMID: 19778432
    6. Maintenance of structure and organization of extracellular matrix comprising chondron and pericellular microenvironment of chondrocytes in articular cartilage is important for distribution of newly synthesized aggrecan monomers within tissue. PMID: 12475642
    7. aggrecan plays a protective role in preventing degradation of collagen fibrils PMID: 12890681
    8. Changes in aggrecan and type II collagen promoter activity in transfected chondrocyte-laden cylindrical constructs were evaluated in response to a range of loading frequencies and durations. PMID: 16691412
    9. AGC1 mRNA expression level was upregulated by multidirectional articular motion. PMID: 17518631
    10. Homozygosity mapping in candidate regions in a small Dexter pedigree suggested aggrecan as the most likely candidate gene. Mutation screening revealed a 4-bp insertion in exon 11 (2266_2267insGGCA) and a second, rarer transition in exon 1 (-198C>T). PMID: 17952705
    11. identified multiple conserved amino acids within regions N- and C-terminal of aggrecan to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 and ADAMTS-5 PMID: 19101611
    12. The objective of this study was to compare patterns of aggrecan processing by chondrocytes and meniscal fibrochondrocytes in tissue explants and cell-agarose constructs. PMID: 19260779

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Aggrecan/versican proteoglycan family
  • 数据库链接：

    KEGG: bta:280985

    STRING: 9913.ENSBTAP00000021512

    UniGene: Bt.4953

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