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  4. Recombinant Beta-amyloid-like protein (apl-1), partial

Recombinant Beta-amyloid-like protein (apl-1), partial

  • 中文名称：
    Recombinant Beta-amyloid-like protein(apl-1) ,partial
  • 货号：
    CSB-YP608820CXY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Beta-amyloid-like protein(apl-1) ,partial
  • 货号：
    CSB-EP608820CXY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Beta-amyloid-like protein(apl-1) ,partial
  • 货号：
    CSB-EP608820CXY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Beta-amyloid-like protein(apl-1) ,partial
  • 货号：
    CSB-BP608820CXY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Beta-amyloid-like protein(apl-1) ,partial
  • 货号：
    CSB-MP608820CXY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    apl-1
  • Uniprot No.：
    Q10651
  • 别名：
    apl-1; C42D8.8Amyloid-beta-like protein
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for normal developmental progression throughout all life stages. Specifically required for the molt stage during all larval transitions and morphogenesis. Acts with heterochronic genes, including members of the let-7 family, to regulate larval stage to adult transition. Acts synergistically with acn-1 in let-7 regulated postembryonic cell division of hypodermal seam cells. Acts in multiple pathways to influence daf-12 and daf-16 activity to in turn regulate physiological and reproductive processes such as body size and egg-laying. May play a role in neurotransmission.
  • 基因功能参考文献：
    1. Data indicate that APL1-D2 binds Cu(I) and Cu(II) too weakly to sustain catalysis which suggests that it plays no significant role in copper handling in C. elegans. PMID: 24276282
    2. present hypothetical models as to how sAPL-1 signaling influences metabolic and developmental pathways. PMID: 23044509
    3. [review] Either loss or overexpression of APL-1 will result in lethality, demonstrating the importance of maintaining APL-1 within homeostatic levels, particularly within neurons. PMID: 22038715
    4. Pan-neuronal expression of APL-1, the Caenorhabditis elegans ortholog of APP, disrupts several behaviors, such as olfactory and gustatory learning behavior and touch habituation. PMID: 22836251
    5. signaling of the released APL-1 fragment modulates multiple metabolic states and that APL-1 is required throughout development. PMID: 22466039
    6. Cholesterol and lrp-1 are involved in the regulation of synaptic transmission, similar to apl-1. PMID: 22363792
    7. a critical cis-regulatory element of apl-1 transcription PMID: 21150118
    8. Loss of apl-1 leads to neurotransmission defects. PMID: 20862215
    9. the x-ray structure of the E2 domain of APL-1 PMID: 19906646
    10. The 5' UTR of the Aplp1 gene lacks any type of CAGA box. PMID: 15208260
    11. APL-1 acts non-cell-autonomously during development. PMID: 17267616
    12. apl-1 expression is upregulated during the last larval stage in hypodermal seam cells which is transcriptionally regulated by hbl-1, lin-41 and lin-42. PMID: 18262516

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein. Early endosome.
  • 蛋白家族：
    APP family
  • 组织特异性：
    Expressed in the head, pharynx, spermatheca, uterus, vulva, tail and ventral neurons. Specifically expressed in nerve ring interneurons, the ventral cord, socket and amphids in the head, with strong expression in junctional cells, including the pharyngeal
  • 数据库链接：

    KEGG: cel:CELE_C42D8.8

    STRING: 6239.C42D8.8a.2

    UniGene: Cel.6164

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